Copper-catalyzed oxidative multicomponent reaction: synthesis of imidazo fused heterocycles with molecular oxygen. Issue 39 (9th August 2018)

• Record Type: Journal Article
• Authors: Li, Xianwei; Wang, Tianzhang; Lu, Yu-Jing; Ji, Shaomin; Huo, Yanping; Liu, Bifu
• Is Part Of: Organic & biomolecular chemistry. Volume 16:Issue 39(2018)
• Page Start: 7143
• Page End: 7151
• Publication Date: 2018-08-09
• Subjects: Chemistry, Organic -- Periodicals; Bioorganic chemistry -- Periodicals; Chemistry, Physical organic -- Periodicals; 547
• DOI: 10.1039/c8ob01532e
• Languages: English
• ISSNs: 1477-0520

Abstract

Abstract : An oxidative cascade that involves multicomponent reaction comprising a terminal alkyne, 2-amino N-heterocycle, benzyl or allylic bromide with molecular oxygen, delivering densely functionalized imidazo fused heterocycles, is achieved. Abstract : An oxidative cascade that involves multicomponent reaction comprising a terminal alkyne, 2-amino N-heterocycle, benzyl or allylic bromide with molecular oxygen, delivering densely functionalized imidazo fused heterocycles, is described. This reaction features a cheap catalyst, a green oxidant, and readily available starting materials, which make the overall synthesis applicable in the quick access to relevant pharmaceutical molecules with imidazole derived heterocycles.