Hygroscopicity of lithium coordination polymers and their solid solutions. Issue 39 (15th August 2018)

• Record Type: Journal Article
• Authors: Lestari, Monica; Lusi, Matteo; O'Leary, Aoife; O'Nolan, Daniel; Zaworotko, Michael J.
• Is Part Of: CrystEngComm. Volume 20:Issue 39(2018)
• Page Start: 5940
• Page End: 5944
• Publication Date: 2018-08-15
• Subjects: Crystals -- Periodicals; Crystal growth -- Periodicals; Crystallography -- Periodicals; Cristaux -- Périodiques; Cristaux -- Croissance -- Périodiques; Cristallographie -- Périodiques; 548
• DOI: 10.1039/c8ce00905h
• Languages: English
• ISSNs: 1466-8033

Abstract

Abstract : Lithium-based coordination polymers and their solid solutions are synthesised and investigated from a pharmaceutical perspective. In particular, the hygroscopicity is measured as a function of composition showing two different behaviours. Abstract : Coordination polymers (CPs) of active pharmaceutical ingredients (APIs) are relatively rare, though recent studies show how these forms can afford improved solubility and stability. Here, the hygroscopicity of two coordination polymers of lithium and their solid solutions is investigated. The two systems exhibit different behaviour, impacting their potential utility as drug substances. In particular, the solid solutions of {[(PRO)Li(MBNZ)1− x (BNZ) x ]} n (1 x ) show lower stability than both the pure compounds whereas in the solid solutions of {[Li2 (SUC)1− x (MAL) x ]} n (2 x ), the hygroscopicity varies more regularly with composition.