Advanced palladium free approach to the synthesis of substituted alkene oxindoles via aluminum-promoted Knoevenagel reaction. Issue 60 (10th October 2018)

• Record Type: Journal Article
• Authors: Novikova, Daria S.; Grigoreva, Tatyana A.; Zolotarev, Andrey A.; Garabadzhiu, Alexander V.; Tribulovich, Vyacheslav G.
• Is Part Of: RSC advances. Volume 8:Issue 60(2018)
• Page Start: 34543
• Page End: 34551
• Publication Date: 2018-10-10
• Subjects: Chemistry -- Periodicals; 540.5
• DOI: 10.1039/c8ra07576j
• Languages: English
• ISSNs: 2046-2069

Abstract

Abstract : A synthetic route for the synthesis of C24, as well as for the design of focused libraries of direct AMPK activators was developed based on a convergent strategy. Abstract : A synthetic route for the synthesis of C24, as well as for the design of focused libraries of direct AMPK activators was developed based on a convergent strategy. The proposed scheme corresponds to the current trends in C–H bond functionalization. The use of aluminum isopropoxide for the Knoevenagel condensation of oxindole with benzophenones is a noticeable point of this work.