Rhodium(iii)-catalyzed C–H activation at the C4-position of indole: switchable hydroarylation and oxidative Heck-type reactions of maleimides. Issue 79 (19th September 2018)

• Record Type: Journal Article
• Authors: Sherikar, Mahadev Sharanappa; Kapanaiah, Raja; Lanke, Veeranjaneyulu; Prabhu, Kandikere Ramaiah
• Is Part Of: Chemical communications. Volume 54:Issue 79(2018)
• Page Start: 11200
• Page End: 11203
• Publication Date: 2018-09-19
• Subjects: Chemistry -- Periodicals; 540
• DOI: 10.1039/c8cc06264a
• Languages: English
• ISSNs: 1359-7345

Abstract

Abstract : A Rh(iii )-catalyzed C–H activation of indole at the C4-position leading to novel and switchable functionalization has been reported by employing a weakly co-ordinating COCF3 group as a directing group. Abstract : A Rh(iii )-catalyzed C–H activation of indole at the C4-position leading to novel and switchable functionalization has been reported by employing a weakly co-ordinating COCF3 group as a directing group. An additive plays an important role in switching the selectivity between 1, 4-addition products and Heck-type products. An acid additive led to the formation of 1, 4-addition products whereas a base additive promotes the formation of Heck-type products. Deuteration studies and control experiments were helpful to propose the mechanism.