Successful treatment of primary donor‐derived human herpesvirus‐8 infection and hepatic Kaposi Sarcoma in an adult liver transplant recipient. Issue 5 (23rd August 2018)

• Record Type: Journal Article
• Authors: Fu, Whitney; Merola, Jonathan; Malinis, Maricar; Lacy, Jill; Barbieri, Andrea; Liapakis, Annmarie H.; Mulligan, David C.; Yoo, Peter S.
• Is Part Of: Transplant infectious disease. Volume 20:Issue 5(2018)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2018-08-23
• Subjects: human herpesvirus‐8 -- liver transplant -- post‐transplant Kaposi Sarcoma; Transplantation of organs, tissues, etc -- Complications -- Periodicals; Communicable diseases -- Periodicals; Infection -- Periodicals; 617.01
• DOI: 10.1111/tid.12966
• Languages: English
• ISSNs: 1398-2273

Abstract

Abstract: Kaposi sarcoma (KS) may rarely occur in transplant recipients through primary human herpesvirus‐8 (HHV‐8) infection from a seropositive donor. This report describes a patient who developed hepatic KS after receiving a split liver transplant from an HHV‐8‐positive donor. The recipient was treated with liposomal doxorubicin after reduction in immunosuppression led to acute cellular rejection. This treatment achieved regression of KS while preserving allograft function, demonstrating a successful therapeutic strategy for this malignancy.