Hydroxypropyl‐β‐cyclodextrin hybrid nanogels as nano‐drug delivery carriers to enhance the solubility of dexibuprofen: Characterization, in vitro release, and acute oral toxicity studies. Issue 6 (4th September 2017)

• Record Type: Journal Article
• Authors: Khalid, Qandeel; Ahmad, Mahmood; Usman Minhas, Muhammad
• Is Part Of: Advances in polymer technology. Volume 37:Issue 6(2018)
• Page Start: 2171
• Page End: 2185
• Publication Date: 2017-09-04
• Subjects: amorphous -- differential scanning calorimetry -- drug delivery systems -- Fourier transform infrared -- host–guest systems -- hybrid nanogels -- hydroxypropyl‐β‐cyclodextrin -- nanotechnology -- radical polymerization -- thermal gravimetric analysis -- toxicity studies; Plastics -- Periodicals; Polymers -- Periodicals; 668.9
• DOI: 10.1002/adv.21876
• Languages: English
• ISSNs: 0730-6679

Abstract

Abstract: The purpose of this study was to develop and characterize hydroxypropyl‐β‐cyclodextrin (HPβCD) hybrid nanogels for solubility enhancement of lipophilic drug, dexibuprofen. HPβCD hybrid nanogels were designed by chemical cross‐linking of hydroxypropyl‐β‐cyclodextrin with 2‐acrylamido‐2‐methyl propane sulfonic acid (AMPS) via free radical polymerization. Loading efficiency, solubilization, zetasizer, FESEM Fourier transform infrared (FTIR), differential scanning calorimetry (DSC), thermal gravimetric analysis (TGA), powder X‐ray diffraction (PXRD), and in vitro drug release analysis were performed for characterization of hybrid nanogels. Efficient solubilization of dexibuprofen has been observed by HPβCD hybrid nanogels. FTIR, TGA, and DSC studies confirmed the formation of new hybrid nanogels and complexation of dexibuprofen with nanogels. XRD analysis revealed loss of dexibuprofen crystallinity in hybrid nanogels. Highly porous and amorphous nanogels showed a significant dexibuprofen release in aqueous medium. In toxicity studies, no significant changes in behavioral, physiological, biochemical, or histopathological parameters of animals endorsed that developed formulations are nontoxic and biocompatible.