An Atropos Biphenyl Bisphosphine Ligand with 2, 2′‐tert‐Butylmethylphosphino Groups for the Rhodium‐Catalyzed Asymmetric Hydrogenation of Enol Esters. Issue 19 (14th August 2018)

• Record Type: Journal Article
• Authors: Jia, Jia; Fan, Dongyang; Zhang, Jian; Zhang, Zhenfeng; Zhang, Wanbin
• Is Part Of: Advanced synthesis & catalysis. Volume 360:Issue 19(2018)
• Page Start: 3793
• Page End: 3800
• Publication Date: 2018-08-14
• Subjects: Atropos -- Asymmetric hydrogenation -- Biphenyl bisphosphine ligand -- P-Stereogenic -- Rhodium; Catalysis -- Periodicals; Organic compounds -- Synthesis -- Periodicals; Chemistry -- Periodicals; Chemistry, Technical -- Periodicals; Chemistry -- Periodicals; Catalysis -- Periodicals; Technology, Pharmaceutical -- Periodicals; 547.2
• DOI: 10.1002/adsc.201800774
• Languages: English
• ISSNs: 1615-4150

Abstract

Abstract: This is an update of our previous work concerning the development of Atropos biphenyl bisphosphine ligands. An unexpected Atropos structural property was confirmed by single crystal X‐ray diffraction and this result is consistent with the computational calculations described in our previous work. This P‐stereogenic bisphosphine ligand possessing a biphenyl backbone and 2, 2′‐ tert ‐butylmethylphosphino groups has been applied to the Rh‐catalyzed asymmetric hydrogenation of enol esters, which has not been widely studied and can be used for the synthesis of several important bioactive compounds. Although there is room for further improvement in enantioselectivity, the results reported herein provide a further understanding of such types of ligands. Abstract :