Effect of curcumin on bone tissue in the diabetic rat: repair of peri-implant and critical-sized defects. Issue 11 (November 2018)

• Record Type: Journal Article
• Authors: Cirano, F.R.; Pimentel, S.P.; Casati, M.Z.; Corrêa, M.G.; Pino, D.S.; Messora, M.R.; Silva, P.H.F.; Ribeiro, F.V.
• Is Part Of: International journal of oral & maxillofacial surgery. Volume 47:Issue 11(2018:Nov.)
• Page Start: 1495
• Page End: 1503
• Publication Date: 2018-11
• Subjects: diabetes mellitus -- curcumin -- dental implants -- osseointegration -- biologic markers -- bone remodelling; Mouth -- Surgery -- Periodicals; Maxilla -- Surgery -- Periodicals; Dentistry -- Periodicals; Dentistry, Operative; Oral Surgical Procedures; Surgery, Oral; Dentistry; Maxilla -- Surgery; Mouth -- Surgery; Electronic journals; Periodicals; 617.52059
• DOI: 10.1016/j.ijom.2018.04.018
• Languages: English
• ISSNs: 0901-5027

Abstract

Abstract: This study determined the effect of curcumin on bone healing in animals with diabetes mellitus (DM). One hundred rats were divided into five groups: DM + PLAC, DM + CURC, DM + INS, DM + CURC + INS, and non-DM (CURC, curcumin; PLAC, placebo; INS, insulin). Critical calvarial defects were created and titanium implants were inserted into the tibiae. Calvarial defects were analyzed histometrically, and BMP-2, OPN, OPG, RANKL, Runx2, Osx, β-catenin, Lrp-5, and Dkk1 mRNA levels were quantified by PCR. The implants were removed for a torque evaluation, the peri-implant tissue was collected for mRNA quantification of the same bone-related markers, and the tibiae were submitted to micro-computed tomography. The DM + CURC + INS and non-DM groups exhibited greater closure of the calvaria when compared to the DM + PLAC group ( P < 0.05). Increased retention of implants was observed in the DM + CURC, DM + CURC + INS, and non-DM groups when compared to the DM + PLAC group ( P < 0.05). CURC improved bone volume and increased bone–implant contact when compared to DM + PLAC ( P < 0.05). In calvarial samples, CURC favourably modulated RANKL/OPG and Dkk1 and improved β-catenin levels when compared to DM + PLAC ( P < 0.05). In peri-implant samples, Dkk1 and RANKL/OPG were down-regulated and BMP-2 up-regulated by CURC when compared to DM + PLAC ( P < 0.05). CURC reverses the harmful effects of DM in bone healing, contributing to the modulation of bone-related markers.