Deconstructing deployment of the innate immune lymphocyte army for barrier homeostasis and protection. Issue 1 (7th October 2018)

• Record Type: Journal Article
• Authors: Almeida, Francisca F.; Jacquelot, Nicolas; Belz, Gabrielle T.
• Is Part Of: Immunological reviews. Volume 286:Issue 1(2018)
• Page Start: 6
• Page End: 22
• Publication Date: 2018-10-07
• Subjects: homeostasis -- innate immunity -- innate lymphoid cells -- mucosal immunity -- protection; Immunology -- Periodicals; Transplantation of organs, tissues, etc -- Periodicals; 616.079
• DOI: 10.1111/imr.12709
• Languages: English
• ISSNs: 0105-2896

Abstract

Summary: The study of the immune system has shifted from a purely dichotomous separation between the innate and adaptive arms to one that is now highly complex and reshaping our ideas of how steady‐state health is assured. It is now clear that immune cells do not neatly fit into these two streams and immune homeostasis depends on continual dialogue between multiple lineages of the innate (including dendritic cells, innate lymphoid cells, and unconventional lymphocytes) and adaptive (T and B lymphocytes) arms together with a finely tuned synergy between the host and microbes which is essential to ensure immune homeostasis. Innate lymphoid cells are critical players in this new landscape. Here, we discuss recent studies that have elucidated in detail the development of ILCs from their earliest progenitors and examine factors that influence their identification and ability to drive immune homeostasis and long‐term immune protection.