Catalyst- and solvent-free mechanochemical synthesis of isoxazoles from N-hydroxybenzimidoyl chlorides and enamino carbonyl compounds. Issue 45 (8th November 2018)
- Record Type:
- Journal Article
- Title:
- Catalyst- and solvent-free mechanochemical synthesis of isoxazoles from N-hydroxybenzimidoyl chlorides and enamino carbonyl compounds. Issue 45 (8th November 2018)
- Main Title:
- Catalyst- and solvent-free mechanochemical synthesis of isoxazoles from N-hydroxybenzimidoyl chlorides and enamino carbonyl compounds
- Authors:
- Xu, Hui
Fan, Guang-Peng
Liu, Zi
Wang, Guan-Wu - Abstract:
- Abstract: A regioselective, solvent-free and catalyst-free synthesis of isoxazoles has been successfully developed under ball milling conditions. Milling the mixtures of N -hydroxybenzimidoyl chlorides and enamino carbonyl compounds in a ball mill at a frequency of 14.6 Hz for 20–60 min afforded isoxazoles in up to 86% yields. A possible reaction mechanism leading to the formation of the observed isoxazoles is proposed. Graphical abstract:
- Is Part Of:
- Tetrahedron. Volume 74:Issue 45(2018)
- Journal:
- Tetrahedron
- Issue:
- Volume 74:Issue 45(2018)
- Issue Display:
- Volume 74, Issue 45 (2018)
- Year:
- 2018
- Volume:
- 74
- Issue:
- 45
- Issue Sort Value:
- 2018-0074-0045-0000
- Page Start:
- 6607
- Page End:
- 6611
- Publication Date:
- 2018-11-08
- Subjects:
- Mechanochemistry -- Solvent-free -- Catalyst-free -- Isoxazoles -- N-Hydroxybenzimidoyl chlorides -- Enamino carbonyl compounds
Chemistry, Organic -- Periodicals
547.005 - Journal URLs:
- http://www.elsevier.com/journals ↗
- DOI:
- 10.1016/j.tet.2018.09.044 ↗
- Languages:
- English
- ISSNs:
- 0040-4020
- Deposit Type:
- Legaldeposit
- View Content:
- Available online (eLD content is only available in our Reading Rooms) ↗
- Physical Locations:
- British Library DSC - 8796.850000
British Library DSC - BLDSS-3PM
British Library STI - ELD Digital store - Ingest File:
- 7954.xml