Recent advances in the enzymatic synthesis of sugar-nucleotides using nucleotidylyltransferases and glycosyltransferases. (November 2018)

• Record Type: Journal Article
• Authors: Ahmadipour, Sanaz; Beswick, Laura; Miller, Gavin J.
• Is Part Of: Carbohydrate research. Volume 469(2018)
• Page Start: 38
• Page End: 47
• Publication Date: 2018-11
• Subjects: Sugar-nucleotide -- Glycosyl-1-phosphate -- Pyrophosphorylase -- Enzymatic synthesis -- Nucleotidylyltransferase; Carbohydrates -- Periodicals; Chemistry, Organic -- Periodicals; Biochemistry -- Periodicals; Carbohydrates -- Periodicals; Chimie organique -- Périodiques; Glucides -- Périodiques; Biochemistry; Carbohydrates; Chemistry, Organic; Periodicals; Electronic journals; 507.78
• DOI: 10.1016/j.carres.2018.09.002
• Languages: English
• ISSNs: 0008-6215

Abstract

Graphical abstract: Sugar-nucleotides are imperative to carbohydrate metabolism and glycoconjugate biosynthesis. Enzymatic methods to access these key materials offer a powerful alternative to traditional chemical synthesis routes. Herein we review recent advances in the enzymatic pyrophosphorylation of glycosyl 1-phosphates for the provision of both native and modified sugar-nucleotides.