A microvenular hemangioma with a rare expression of progesterone receptor immunocreativity and a review of the literature. (19th August 2018)

• Record Type: Journal Article
• Authors: Juan, Yi‐Chen; Chen, Chih‐Jung; Hsiao, Cheng‐Hsiang; Chiu, Tsu‐Man
• Is Part Of: Journal of cutaneous pathology. Volume 45:Number 11(2018)
• Page Start: 847
• Page End: 850
• Publication Date: 2018-08-19
• Subjects: immunohistochemistry -- microvenular hemangioma -- progesterone receptor -- vascular tumor; Skin -- Diseases -- Periodicals; Dermatology -- Periodicals; 616
• DOI: 10.1111/cup.13322
• Languages: English
• ISSNs: 0303-6987

Abstract

Abstract : Microvenular hemangioma (MVH) is a rare benign vascular tumor with a controversial etiology, but hormone receptor alterations might be involved. We report a case of MVH in a 41‐year‐old Taiwanese woman who presented with a 1.5 × 1 cm violaceous plaque on left thigh that had appeared 1 year previously. She had taken oral contraceptives for several years and stopped 1 year prior to presentation. Histologically, the tumor was composed of small and compressed venous structures infiltrating in the dermis and subcutis. Immunohistochemically, the tumor cells displayed negative immunoreactivity for human herpesvirus‐8 and positive immunoreactivity for smooth muscle actin and progesterone receptor (PR). Taken together with the patient's medical hormone therapy history and the evidence of PR immunoreactivity, our findings support that progesterone may be associated with the tumorigenesis of MVH.