Forsskamide, a new ceramide from aerial parts of Forsskaolea tenacissima Linn. Issue 20 (18th October 2018)

• Record Type: Journal Article
• Authors: Assaf, Hamdy K.; Nafady, Alaa M.; Allam, Ahmed E.; Hamed, Ashraf N. E.; Kamel, Mohamed S.; Shimizu, Kuniyoshi
• Is Part Of: Natural product research. Volume 32:Issue 20(2018)
• Page Start: 2452
• Page End: 2456
• Publication Date: 2018-10-18
• Subjects: Forsskaolea tenacissima -- Urticaceae -- Forsskamide -- ceramide and cytotoxicity; Natural products -- Periodicals; Natural products -- Research -- Periodicals; Biological Factors -- Periodicals; Biological Products -- Periodicals; 547
• DOI: 10.1080/14786419.2017.1419234
• Languages: English
• ISSNs: 1478-6419

Abstract

Abstract: Although the various folk medicine uses and the biological activity of Forsskaolea tenacissima L., few chemical constituents of this plant have been reported, this provoked us to make our study. Forsskamide, a new ceramide was isolated from aerial parts of F. tenacissima L. (Urticaceae). The chemical structure was established by different spectroscopic methods ( 1 H, 13 C-NMR, HMBC, HSQC, ROESY, FAB-MS and HR-FAB-MS). Forsskamide showed a moderate cytotoxic activity by (MTT) method against human colorectal carcinoma cell line (HCT-116) with IC50 33.25 μM in comparison with 5-fluorouracil IC50 26.42 μM. While, it did not show any activity against human hepatocarcinaoma cell line (HepG-2). Abstract :