Colorectal carcinoma: Ex vivo evaluation using q‐space imaging; Correlation with histopathologic findings. Issue 4 (30th March 2018)

• Record Type: Journal Article
• Authors: Yamada, Ichiro; Hikishima, Keigo; Yoshino, Norio; Sakamoto, Junichiro; Miyasaka, Naoyuki; Yamauchi, Shinichi; Uetake, Hiroyuki; Yasuno, Masamichi; Saida, Yukihisa; Tateishi, Ukihide; Kobayashi, Daisuke; Eishi, Yoshinobu
• Is Part Of: Journal of magnetic resonance imaging. Volume 48:Issue 4(2018)
• Page Start: 1059
• Page End: 1068
• Publication Date: 2018-03-30
• Subjects: colon -- rectum -- colorectal carcinoma -- q‐space imaging -- diffusion‐weighted imaging -- MR imaging; Magnetic resonance imaging -- Periodicals; 616
• DOI: 10.1002/jmri.26018
• Languages: English
• ISSNs: 1053-1807

Abstract

Abstract : Background: Although the prognosis of colorectal carcinoma (CRC) patients depends on the histologic grade (HG) and lymph node metastasis (LNM), accurate preoperative assessment of these prognostic factors is often difficult. Purpose: To assess the HG and extent of LNM by q‐space imaging (QSI) for preoperative diagnosis of CRC. Study Type: Prospective. Specimen: A total of 20 colorectal tissue samples containing adenocarcinomas and resected lymph nodes (LNs). Field Strength/Sequence: QSI was performed with a 3T MRI system using a diffusion‐weighted echo‐planar imaging sequence: repetition time, 10, 000 msec; echo time, 216 or 210 msec; field of view, 113 × 73.45 mm; matrix, 120 × 78; section thickness, 4 mm; and 11 b values ranging from 0 to 9000 s/mm 2 . Assessment: The mean displacement (MDP; μm), zero‐displacement probability (ZDP; arbitrary unit [a.u.]), kurtosis (K; a.u.), and apparent diffusion coefficient (ADC) were analyzed by two observers and compared with histopathologic findings. Statistical Tests: Spearman's rank correlation coefficient, Mann–Whitney U ‐test, and ROC curve analyses. Results: For all 20 carcinomas, the MDP, ZDP, K, and ADC were 8.87 ± 0.37 μm, 82.0 ± 6.2 a.u., 74.3 ± 3.0 a.u., and 0.219 ± 0.040 × 10 −3 mm 2 /s, respectively. The MDP ( r = –0.768; P < 0.001), ZDP ( r = 0.768; P < 0.001), and K ( r = 0.785; P < 0.001) were significantly correlated with the HG of CRC, but not the ADC ( r = 0.088; P = 0.712). There were also significant differences in the MDP, ZDP, and K between metastatic and nonmetastatic LNs (all, P < 0.001), but not the ADC ( P = 0.082). In the HG of CRC and LNM, the area under the curve was significantly greater for MDP, ZDP, and K than for ADC. Data Conclusion: QSI provides useful diagnostic information to assess the HG and extent of LNM in CRC. Level of Evidence: 1 Technical Efficacy: Stage 2 J. Magn. Reson. Imaging 2018;48:1059–1068.