Diversity‐Oriented Synthesis of Functionalized Imidazopyridine Analogues with Anti‐Cancer Activity through a Transition‐Metal Free, One‐pot Cascade Reaction. Issue 19 (9th August 2018)

• Record Type: Journal Article
• Authors: Song, Gui‐Ting; McConnell, Nicholas; Chen, Zhong‐Zhu; Yao, Xiao‐Fang; Huang, Jiu‐Hong; Lei, Jie; Lin, Hui‐Kuan; Frett, Brendan; Li, Hong‐yu; Xu, Zhi‐Gang
• Is Part Of: Advanced synthesis & catalysis. Volume 360:Issue 19(2018)
• Page Start: 3655
• Page End: 3661
• Publication Date: 2018-08-09
• Subjects: Imidazopyridines -- Anti-cancer -- One-pot -- three-component reaction -- multicomponent reactions (MCRs); Catalysis -- Periodicals; Organic compounds -- Synthesis -- Periodicals; Chemistry -- Periodicals; Chemistry, Technical -- Periodicals; Chemistry -- Periodicals; Catalysis -- Periodicals; Technology, Pharmaceutical -- Periodicals; 547.2
• DOI: 10.1002/adsc.201800728
• Languages: English
• ISSNs: 1615-4150

Abstract

Abstract: A transition‐metal free, high yielding and efficient three‐component reaction was designed and incorporated into two sequential oxidation and cyclization reaction cascades in one‐pot with the assistance of microwave irradiation. A chemical collection of functionalized 3‐substituted imidazopyridines was prepared by means of the mild reaction and simple operational procedure. The reaction has a broad tolerance for a variety of substituted carbonyl aldehydes, anilines and 2‐phenyl‐imidazo[1, 2‐ a ]pyridines. Screening in several cancer cell lines was conducted. Compound9 i exhibited good potency against HeLa cell lines and this work validated the feasibility of the methodology for generating bioactive compounds. Abstract :