The effects of mitochondria-associated long noncoding RNAs in cancer mitochondria: New players in an old arena. (November 2018)

• Record Type: Journal Article
• Authors: Zhao, Yijing; Sun, Lemeng; Wang, Rachel R.; Hu, Ji-Fan; Cui, Jiuwei
• Is Part Of: Critical reviews in oncology/hematology. Volume 131(2018)
• Page Start: 76
• Page End: 82
• Publication Date: 2018-11
• Subjects: ANRIL Antisense non-coding RNA in the INK4 locus -- ASO Antisense oligonucleotides -- CRM1 Chromosome region maintenance 1 -- GAS5 Growth arrest-specific transcript 5 -- HOTAIR Hox Transcript Antisense Intergenic RNA -- mtDNAs Mitochondrial DNAs -- mtlncRNAs Mitochondrial-encoded lncRNAs lncRNA -- ntmtlncRNAs Nuclear-transported mitochondria-associated lncRNAs -- MAC Mitochondria apoptosis induced channel -- lncRNAs Long noncoding RNAs -- RS Replicative senescence -- SIPS Stress-induced premature senescence; Mitochondria -- Long noncoding RNAs -- Cancer -- Metabolism -- Apoptosis; Oncology -- Periodicals; Hematology -- Periodicals; 616.994
• DOI: 10.1016/j.critrevonc.2018.08.005
• Languages: English
• ISSNs: 1040-8428

Abstract

Abstract: LncRNAs, as new players in the old battle against cancer, are significant components of gene regulatory networks. Mitochondria-associated lncRNAs have newly been discovered to work in concert with transcription factors and epigenetic regulators to modulate mitochondrial gene expression and mitochondrial function. Many mitochondria-associated lncRNAs regulate mitochondrial biosynthesis, bioenergetics, apoptosis and possibly govern the cross-talk of mitochondria with nuclei. The complexity of mitochondria-associated lncRNAs is now just starting to envisage. In this review, we collected available evidence that reinforces the importance of mitochondria-associated lncRNA in cancer metabolism, apoptosis, and cell senescence. For the non-exhaustive list of mitochondria-associated lncRNAs, we identified 18 lncRNAs in total (mitochondria-encoded lncRNAs or nuclei encoded mitochondria function associated lncRNAs) as emerging new players in cancer mitochondrial function. As lncRNAs exhibit cancer-type-specific expression patterns, they are attractive targets for selective therapeutic interventions. Manipulation of their function may thus represent a valuable strategy for future cancer treatment.