Intravoxel incoherent motion MRI for differentiating sinonasal small round cell malignant tumours (SRCMTs) from Non-SRCMTs: comparison and correlation with dynamic contrast-enhanced MRI. Issue 11 (November 2018)

• Record Type: Journal Article
• Authors: Zhong, Y.; Xiao, Z.; Tang, Z.; Qiang, J.; Wang, R.
• Is Part Of: Clinical radiology. Volume 73:Issue 11(2018)
• Page Start: 966
• Page End: 974
• Publication Date: 2018-11
• Subjects: Medical radiology -- Periodicals; Radiotherapy -- Periodicals; Radiotherapy -- Periodicals; Radiology -- Periodicals; Societies, Medical -- Periodicals; Medical radiology; Radiotherapy; Electronic journals; Periodicals; 616.0757
• DOI: 10.1016/j.crad.2018.07.097
• Languages: English
• ISSNs: 0009-9260

Abstract

Abstract : Aim: To investigate the value of intravoxel incoherent motion (IVIM) in the differentiation of sinonasal small round cell malignant tumours (SRCMTs) from non-SRCMTs and to compare and correlate these results with those of dynamic contrast-enhanced (DCE) magnetic resonance imaging (MRI). Materials and methods: Ninety patients with histologically confirmed sinonasal malignant tumours (53 SRCMTs and 37 non-SRCMTs) who underwent conventional MRI, IVIM, and DCE-MRI before treatment were enrolled. The IVIM and DCE-MRI parameters were measured. Statistical analyses were performed using Student's t -tests, receiver operating characteristic (ROC) curve analyses, and Spearman's correlation coefficients. Results: A lower pure diffusion coefficient (D) value and a higher pseudo-diffusion coefficient (D*) value were found in the sinonasal SRCMTs than in the non-SRCMTs ( p< 0.001 and p= 0.011, respectively). Moreover, the mean extravascular extracellular space volume ratio (Ve ) of the SRCMTs was significantly lower than that of the non-SRCMTs ( p= 0.020). ROC curve analysis showed that the diagnostic performance of D outperformed those of the other perfusion and diffusion parameters. A cut-off D value of 0.56 ×10 −3 mm 2 /s yielded a sensitivity of 80.4%, a specificity of 75%, and an accuracy of 78.2%, with an AUC of 0.825. Significant but poor-to-fair correlations were found between the parameters from IVIM and DCE-MRI. Conclusions: The D and D* values of IVIM and the Ve value of DCE-MRI are helpful in distinguishing sinonasal SRCMTs from non-SRCMTs, with the D values having the best diagnostic efficiency. Highlights: IVIM and DCE-MRI are helpful for differentiating SRCMTs from non-SRCMTs. The D derived from IVIM is the most useful imaging biomarker for distinguishing SRCMTs from non-SRCMTs. There were some significant but poor-to-moderate correlations between IVIM and DCE-MRI parameters.