Multicentric Benign Epithelial Inclusions in a Free-ranging Risso's Dolphin (Grampus griseus). Issue 2 (August 2016)

• Record Type: Journal Article
• Authors: Diaz-Delgado, J.; Quesada-Canales, O.; Arbelo, M.; Sierra, E.; Edwards, J.F.; Suarez-Bonnet, A.; Santana-Suarez, C.; Espinosa de los Monteros, A.; Fernandez, A.
• Is Part Of: Journal of comparative pathology. Volume 155:Issue 2/3(2016)
• Page Start: 267
• Page End: 271
• Publication Date: 2016-08
• Subjects: epithelial inclusions -- reactive mesothelium -- Risso's dolphin; Veterinary pathology -- Periodicals; Veterinary therapeutics -- Periodicals; Pathology, Comparative -- Periodicals; Therapeutics -- Periodicals; Pathology, Veterinary -- Periodicals; 636.089607
• DOI: 10.1016/j.jcpa.2016.06.002
• Languages: English
• ISSNs: 0021-9975

Abstract

Summary: This report describes the histological and immunohistochemical features of multicentric, benign, epithelial inclusions (BEIs) in a free-ranging, adult, female Risso's dolphin ( Grampus griseus ). The differential diagnoses included ectopic hamartomatous epithelial inclusions, non-Müllerian choristoma, Müllerian choristoma and low-grade metastatic carcinoma/mesothelioma. The most likely diagnosis of such BEIs was multicentric, embolic, reactive mesothelium, as suggested by cytomorphological and immunophenotypical features of the BEIs, the occurrence of focal pleural rupture and the immunophenotype of the pleural mesothelium. The former represents a pathological condition not previously reported in a marine mammal species, rarely described in animals, and relatively infrequently recognized in man.