Cylindrical polymer brushes – Anisotropic building blocks, unimolecular templates and particulate nanocarriers. (19th August 2016)

• Record Type: Journal Article
• Authors: Müllner, Markus; Müller, Axel H.E.
• Is Part Of: Polymer. Volume 98(2016)
• Page Start: 389
• Page End: 401
• Publication Date: 2016-08-19
• Subjects: Molecular brushes -- Self-assembly -- Template chemistry -- Hybrids -- Nanomedicine; Polymers -- Periodicals; Polymerization -- Periodicals; Polymères -- Périodiques; Polymérisation -- Périodiques; 547.7
• DOI: 10.1016/j.polymer.2016.03.076
• Languages: English
• ISSNs: 0032-3861

Abstract

Abstract: This article presents an overview of the latest key developments and research activities in the area of cylindrical polymer brushes (CPBs), also known as 'molecular bottlebrushes'. CPBs consist of a polymer backbone containing polymer side chains that cause the backbone to extend and adopt a worm-like conformation. The extent of backbone stretching and the aspect ratio of CPBs is determined by the length and grafting density of the side chains. The latest developments in controlled/living polymerisation techniques led to novel and more efficient ways of producing delicate polymer architectures, such as block copolymer CPBs, and resulted in a considerable expansion of the field of application for these soft anisotropic materials. In this feature article, we focus on important recent findings and applications in the areas concerning solution and bulk self-assembly of block copolymer CPBs, unimolecular templating and brush-based drug delivery systems in nanomedicine. Graphical abstract: Highlights: Cylindrical polymer brushes (CPBs) are produced via three grafting methods, or a combination thereof. Advances in controlled polymerisation techniques allows for the synthesis of novel block copolymer CPBs. The tuneable self-assembly of block copolymer CPBs in bulk and solution provides a toolbox to produce functional materials. The shape-persistent and compartmentalised nature of CPBs offers scaffolds for one-dimensional hybrid materials. Densely grafted brushes present opportunities in nanocarrier design for nanomedicine.