A facile and expeditious approach to substituted 1H-pyrazoles catalyzed by iodine. Issue 24 (15th June 2016)

• Record Type: Journal Article
• Authors: Zhang, Hailei; Wei, Qian; Zhu, Guodong; Qu, Jingping; Wang, Baomin
• Is Part Of: Tetrahedron letters. Volume 57:Issue 24(2016)
• Page Start: 2633
• Page End: 2637
• Publication Date: 2016-06-15
• Subjects: Metal-free -- α, β-Unsaturated carbonyl compounds -- Sulfonyl hydrazides -- Iodine catalysis -- Pyrazoles; Chemistry, Organic -- Periodicals; 547.005
• DOI: 10.1016/j.tetlet.2016.05.020
• Languages: English
• ISSNs: 0040-4039

Abstract

Graphical abstract: Highlights: A facile and expeditious approach to 1 H -pyrazoles is developed. Starting materials are α, β-unsaturated ketones/aldehydes and sulfonyl hydrazide. The reaction is catalyzed by as low as 2 mol % I2 . The process features simple conditions, high yield, and broad substrate scope. Abstract: A facile and expeditious method for the synthesis of 1 H -pyrazoles by the reaction of α, β-unsaturated aldehydes/ketones and sulfonyl hydrazide catalyzed by as low as 2 mol % I2 has been demonstrated. This synthetic system features simple operation and mild reaction conditions, and displays a broad functional group tolerance furnishing good to excellent yields.