The impact of asymmetric organocatalysis in dearomatization and aromatization of carbocycles: increasing molecular complexity and diversity. Issue 24 (15th June 2016)

• Record Type: Journal Article
• Authors: Pantaine, Loïc; Moreau, Xavier; Coeffard, Vincent; Greck, Christine
• Is Part Of: Tetrahedron letters. Volume 57:Issue 24(2016)
• Page Start: 2567
• Page End: 2574
• Publication Date: 2016-06-15
• Subjects: Asymmetric catalysis -- Organocatalysis -- Aromatization -- Polyaromatic compounds; Chemistry, Organic -- Periodicals; 547.005
• DOI: 10.1016/j.tetlet.2016.05.012
• Languages: English
• ISSNs: 0040-4039

Abstract

Graphical abstract: Highlights: Combination of organocatalysis with either making or breaking aromaticity is powerful. Dearomatization/organocatalysis enables the preparation of 3D molecules. Chiral polyaromatic architectures are prepared by enantioselective organocatalysis. Abstract: The combination of asymmetric organocatalysis with either making or breaking aromaticity, in a single vessel, has known a rapid development over the last decade. This is due to its success in producing complex molecular architectures efficiently while maintaining a good control over diastereo- and enantioselectivities. This digest will offer a broad summary of the advances in this field, focusing primarily on carbocycles, and will be divided into two main parts: the first will concern combining asymmetric organocatalysis with dearomatization, the second with rearomatization.