A mild and selective protecting and reversed modification of thiols. Issue 24 (15th June 2016)

• Record Type: Journal Article
• Authors: Li, Xiangmin; Li, Hongxian; Yang, Wei; Zhuang, Jinchen; Li, Hao; Wang, Wei
• Is Part Of: Tetrahedron letters. Volume 57:Issue 24(2016)
• Page Start: 2660
• Page End: 2663
• Publication Date: 2016-06-15
• Subjects: Thiols -- Bromomaleimide -- Protecting -- Deprotecting -- Selective; Chemistry, Organic -- Periodicals; 547.005
• DOI: 10.1016/j.tetlet.2016.05.027
• Languages: English
• ISSNs: 0040-4039

Abstract

Graphical abstract: Highlights: A mild protecting and reversed modification of thiols has been reported. The selectivity of thiol from other functional groups is very good. The protecting groups can be cleaved using low equivalent of DTT quickly. Abstract: One selective thiol-protecting study has been investigated for a wide range of thiols including general thiols and thiols containing multiple functional groups. The reactions of bromomaleimides and thiols under the mild condition afforded the protected products in excellent yields. The thiols can be recovered very quickly using dithiothreitol (DTT) under the mild condition.