RNA binding proteins implicated in Xist-mediated chromosome silencing. (August 2016)

• Record Type: Journal Article
• Authors: Moindrot, Benoit; Brockdorff, Neil
• Is Part Of: Seminars in cell & developmental biology. Volume 56(2016)
• Page Start: 58
• Page End: 70
• Publication Date: 2016-08
• Subjects: X chromosome inactivation -- Xist -- Chromatin -- Non-coding RNA -- Epigenetic; Cytology -- Periodicals; Developmental biology -- Periodicals; 571.6
• DOI: 10.1016/j.semcdb.2016.01.029
• Languages: English
• ISSNs: 1084-9521

Abstract

Abstract: Chromosome silencing by Xist RNA occurs in two steps; localisation in cis within the nuclear matrix to form a domain that corresponds to the territory of the inactive X chromosome elect, and transduction of silencing signals from Xist RNA to the underlying chromatin. Key factors that mediate these processes have been identified in a series of recent studies that harnessed comprehensive proteomic or genetic screening strategies. In this review we discuss these findings in light of prior knowledge both of Xist-mediated silencing and known functions/properties of the novel factors.