An association between PLA2G6 and PLA2G4C gene polymorphisms and schizophrenia risk and illness severity in a Croatian population. (June 2017)

• Record Type: Journal Article
• Authors: Nadalin, Sergej; Buretić-Tomljanović, Alena
• Is Part Of: Prostaglandins, leukotrienes, and essential fatty acids. Volume 121(2017)
• Page Start: 57
• Page End: 59
• Publication Date: 2017-06
• Subjects: ANOVA one-way analysis of variance -- ARA arachidonic acid (20:4n-6) -- CI confidence interval -- OR odds ratio -- PLA2 phospholipase A2 -- iPLA2β calcium-independent phospholipase A2 beta -- cPLA2γ cytosolic phospholipase A2 gamma -- PANSS Positive and Negative Syndrome Scale -- χ2 test chi square test; Age of onset -- PLA2G4C gene polymorphism -- PLA2G6 gene polymorphism -- Positive and Negative Syndrome Scale -- Schizophrenia; Lipids -- Periodicals; Unsaturated fatty acids -- Periodicals; Prostaglandins -- Periodicals; Leukotrienes -- Periodicals; Fatty Acids, Unsaturated -- Periodicals; Acides gras insaturés -- Périodiques; Prostaglandines -- Périodiques; Leucotriènes -- Périodiques; Lipides -- Périodiques; 612.01577
• DOI: 10.1016/j.plefa.2017.06.003
• Languages: English
• ISSNs: 0952-3278

Abstract

Abstract: We investigated the allele and genotype frequency of the rs4375 and rs1549637 polymorphisms in phospholipase A2 (PLA2)G6 and PLA2G4C genes in 203 patients with schizophrenia and 191 controls in a Croatian population. We hypothesized that these polymorphic variations might influence the age of schizophrenia onset and Positive and Negative Syndrome Scale psychopathology (PANSS) data. We detected a significant overrepresentation of the PLA2G6-CT and PLA2G4C-AT genotype combination in patients compared with controls (14.7% vs. 7.3%, P < 0.05). The combined PLA2G6/PLA2G4C heterozygosity was associated with about a two-fold higher schizophrenia risk. We found no significant influence of the PLA2G6 and PLA2G4C polymorphisms on mean age at first hospital admission (P > 0.05) and that the investigated polymorphisms significantly influenced the clinical psychopathology only in male patients. The PLA2G4C polymorphism accounted for approximately 12% of negative symptom severity; whereas, the PLA2G6/PLA2G4C interaction contributed to a similar extent to total PANSS symptom variations. Highlights: We investigated the role of PLA2G6 and PLA2G4C gene polymorphisms in schizophrenia. The investigated polymorphisms alone do not contribute to schizophrenia risk/onset. The interaction between the polymorphisms contributes to schizophrenia risk. The PLA2G4C polymorphism alone influences psychopathology data in males. The PLA2G6/PLA2G4C interaction also influences psychopathology data in males.