Effect of target probability on pre-stimulus brain activity. (13th May 2016)

• Record Type: Journal Article
• Authors: Lucci, G.; Berchicci, M.; Perri, R.L.; Spinelli, D.; Di Russo, F.
• Is Part Of: Neuroscience. Volume 322(2016)
• Page Start: 121
• Page End: 128
• Publication Date: 2016-05-13
• Subjects: ANOVA Analysis of Variance -- BP Bereitschaftspotential -- CEs commission errors -- DLPC dorsolateral prefrontal cortex -- EEG electroencephalographic -- ERPs event-related potentials -- LRP Lateralized Readiness Potential -- Oms omission errors -- PFC prefrontal cortex -- pN prefrontal negativity -- RTs response times -- SAT speed–accuracy tradeoff -- SMA Supplementary Motor Area; event related potentials (ERPs) -- Bereitschaftspotential (BP) -- prefrontal negativity (pN) -- stimulus probability -- speed–accuracy system -- decision-making; Neurochemistry -- Periodicals; Neurophysiology -- Periodicals; Neurology -- Periodicals; Neurochimie -- Périodiques; Neurophysiologie -- Périodiques; Neurochemistry; Neurophysiology; Electronic journals; Periodicals; Electronic journals; 612.8
• DOI: 10.1016/j.neuroscience.2016.02.029
• Languages: English
• ISSNs: 0306-4522

Abstract

Highlights: We investigate the effect of target probability on the pre-stimulus ERP. The BP was larger for frequent targets and the right pN was larger for rare target. The BP and the pN could be ERP indices of the speed–accuracy system. The BP could be related to the subjective baseline of perceptual decision. The pN could be related to the threshold response setting in decision-making. Abstract: Studies on perceptual decision-making showed that manipulating the proportion of target and non-target stimuli affects the behavioral performance. Tasks with high frequency of targets are associated to faster response times (RTs) conjunctively to higher number of errors (reflecting a response bias characterized by speed/accuracy trade-off) when compared to conditions with low frequency of targets. Electroencephalographic studies well described modulations of post-stimulus event-related potentials as effect of the stimulus probability; in contrast, in the present study we focused on the pre-stimulus preparatory activities subtending the response bias. Two versions of a Go/No-go task characterized by different proportion of Go stimuli (88% vs. 12%) were adopted. In the task with frequent go trials, we observed a strong enhancement in the motor preparation as indexed by the Bereitschaftspotential (BP, previously associated with activity within the supplementary motor area), faster RTs, and larger commission error rate than in the task with rare go trials. Contemporarily with the BP, a right lateralized prefrontal negativity (lateral pN, previously associated with activity within the dorsolateral prefrontal cortex) was larger in the task with rare go trial. In the post-stimulus processing stage, we confirmed that the N2 and the P3 components were larger for rare trials, irrespective of the Go/No-go stimulus category. The increase of activities recorded in the preparatory phase related to frequency of targets is consistent with the view proposed in accumulation models of perceptual decision for which target frequency affects the subjective baseline, reducing the distance between the starting-point and the response boundary, which determines the response speed.