Effects of central administration of oxytocin-saporin cytotoxin on chronic inflammation and feeding/drinking behaviors in adjuvant arthritic rats. (16th May 2016)

• Record Type: Journal Article
• Authors: Matsuura, Takanori; Kawasaki, Makoto; Hashimoto, Hirofumi; Yoshimura, Mitsuhiro; Motojima, Yasuhito; Saito, Reiko; Ueno, Hiromichi; Maruyama, Takashi; Sabanai, Ken; Mori, Toshiharu; Ohnishi, Hideo; Sakai, Akinori; Ueta, Yoichi
• Is Part Of: Neuroscience letters. Volume 621(2016)
• Page Start: 104
• Page End: 110
• Publication Date: 2016-05-16
• Subjects: AA adjuvant arthritis -- AVP arginine vasopressin -- CCK cholecystokinin -- CNS central nervous system -- i.c.v. intracerebroventricular -- i.p. intraperitoneal -- i.t. intrathecal -- M. butyricum Mycobacterium butyricum -- NTS nucleus of the solitary tract -- OXT oxytocin -- OTR oxytocin receptor -- PVN paraventricular nucleus -- SEM standard error of the mean -- SAP saporin -- s.c. subcutaneous; Oxytocin -- Saporin -- Adjuvant arthritis -- Feeding; Neurology -- Periodicals; Neurology -- Periodicals; Research -- Periodicals; Neurologie -- Périodiques; Neuroanatomie -- Périodiques; Neuropharmacologie -- Périodiques; Neurophysiologie -- Périodiques; Neurology; Periodicals; Electronic journals; 617.48
• DOI: 10.1016/j.neulet.2016.04.010
• Languages: English
• ISSNs: 0304-3940

Abstract

Highlights: The arthritis index as a marker of chronic inflammation was enhanced in AA rats pretreated with OXT-SAP administered intrathecally. Suppression of food intake was attenuated transiently in AA rats pretreated with OXT-SAP administered fourth intracerebroventricularly. OXT-ergic pathways may be involved in anti-inflammation at the spinal level and suppression of feeding behavior at the forebrain-brainstem level in AA rats. Abstract: An increase in the arthritis index as a marker of chronic inflammation and suppression of food intake are observed in adjuvant arthritic (AA) rats. Our previous study demonstrated that central oxytocin (OXT)-ergic pathways were activated potently in AA rats. In the present study, OXT-saporin (SAP) cytotoxin, which chemically disrupts OXT signaling was administered centrally to determine whether central OXT may be involved in the developments of chronic inflammation and alteration of feeding/drinking behavior in AA rats. The arthritis index was significantly enhanced in AA rats pretreated with OXT-SAP administered intrathecally (i.t.) but not intracerebroventricularly (i.c.v.). Suppression of food intake was significantly attenuated transiently in AA rats pretreated with OXT-SAP administered i.c.v. but not i.t. Suppression of drinking behavior was not affected by i.t. or i.c.v. administration of OXT-SAP in AA rats. In addition, intraperitoneal administration of an OXT receptor antagonist did not change the arthritis index or feeding/drinking behavior in AA rats. These results suggest that central OXT-ergic pathways may be involved in anti-inflammation at the spinal level and suppression of feeding behavior at the forebrain-brainstem level in AA rats.