Thaliporphine, an alkaloid from Neolitsea konishii, exerts antioxidant, anti-inflammatory, and anti-apoptotic responses in guinea pig during cardiovascular collapse in inflammatory disease. (October 2016)

• Record Type: Journal Article
• Authors: Ku, Hui-Chun; Lee, Shih-Yi; Lee, Shoei-Sheng; Su, Ming-Jai
• Is Part Of: Journal of functional foods. Volume 26(2016)
• Page Start: 57
• Page End: 64
• Publication Date: 2016-10
• Subjects: Thaliporphine -- Cardiovascular -- Reactive oxygen species -- QT interval -- Apoptosis -- Inflammatory; Lipopolysaccharide (PubChem CID: 11970143) -- Thaliporphine (PubChem CID: 100020) -- Triphenyltetrazolium chloride (PubChem CID: 9283) -- 1400W hydrochloride (PubChem CID: 2733515) -- Pentobarbital (PubChem CID: 23676152) -- Formaldehyde (PubChem CID: 712) -- Laurolitsine (PubChem CID: 22179); LPS lipopolysaccharide -- ROS reactive oxygen species -- RNS reactive nitrogen species (RNS) -- iNOS inducible form of nitric oxide synthesis -- NO nitric oxid -- eNOS endothelial nitric oxide synthase -- ECG electrocardiogram -- hERG human ether-à-go-go-related gene -- JNK c-Jun N-terminal kinases -- TNF-α tumour necrosis factor-α -- SOD superoxide dismutase; Functional foods -- Analysis -- Periodicals; Food -- Biotechnology -- Periodicals; Nutrition -- Periodicals; 613.2
• DOI: 10.1016/j.jff.2016.07.002
• Languages: English
• ISSNs: 1756-4646

Abstract

Highlights: Thaliporphine is an alkaloid in Neolitsea konishii . Thaliporphine alleviated oxidative stress and inflammatory response. Thaliporphine inhibited hyperglycaemic response during cardiovascular collapse in inflammatory disease. Thaliporphine protected heart against injury and prevented QT interval prolongation. Abstract: Excessive production of inflammatory cytokines and reactive oxygen species causes circulatory abnormalities leading to insufficient oxygen supply, which results in organ ischaemia and failure. Cardiovascular collapse enhances the risk of death in inflammatory disease. The present study examined the protective effects of thaliporphine, an alkaloid derived from Neolitsea konishii, during cardiovascular collapse in inflammatory disease, which was induced by LPS injection following coronary artery occlusion in guinea pig. Thaliporphine alleviated oxidative stress by preserving SOD activity and accompanied with the alleviation in inflammatory response, was observed to decrease NO, TNF-α secretion and hyperglycaemic response. In addition, thaliporphine inhibited cell death-related pathways activation, as seen by reduced JNK phosphorylation, bax expression, and capase-3 activity, leading to the reduction of myocardial infarct size and prolongation of QT interval in heart. The findings indicate that thaliporphine induces antioxidant, anti-inflammatory, and anti-apoptotic effects and may be developed for the prevention of inflammatory disease with cardiovascular system disorder.