Potential effects of α-mangostin in the prevention and treatment of hepatocellular carcinoma. (October 2016)

• Record Type: Journal Article
• Authors: Cai, Nan; Xie, Shu-Juan; Qiu, Dong-Bo; Jia, Chang-Chang; Du, Cong; Liu, Wei; Chen, Jia-Jie; Zhang, Qi
• Is Part Of: Journal of functional foods. Volume 26(2016)
• Page Start: 309
• Page End: 318
• Publication Date: 2016-10
• Subjects: α-Mangostin -- Hepatocellular carcinoma -- Cancer prevention -- Cancer treatment; α-Mangostin (PubChem CID: 5281650) -- Doxorubicin (PubChem CID: 31703); Functional foods -- Analysis -- Periodicals; Food -- Biotechnology -- Periodicals; Nutrition -- Periodicals; 613.2
• DOI: 10.1016/j.jff.2016.08.014
• Languages: English
• ISSNs: 1756-4646

Abstract

Highlights: α-Mangostin inhibited the proliferation of HCC and transformed hepatic cells. α-Mangostin reversed doxorubicin-resistance in the HCC cells induced by IL-6. α-Mangostin reduced the percentage of CD133 and CD44 positive stem-like HCC cells. α-Mangostin suppressed the expression of key stemness transcription factors. Abstract: α-Mangostin, a xanthone derivative from the pericarp of mangosteen, exerts both anti-proliferative and cytotoxic effects on various cancers. However, the effect of α-mangostin on hepatocellular carcinoma (HCC) cells has not yet been fully determined. Therefore, the present study investigated the anti-proliferative effect of α-mangostin on HCC cells. α-Mangostin inhibited the proliferation of HCC and malignantly transformed hepatic cells. In addition, α-mangostin induced G0/G1 phase cell cycle arrest. Furthermore, α-mangostin also reversed doxorubicin-resistance in the HCC cells induced by IL-6. Moreover, the percentage of CD133, CD44 and EpCAM positive stem-like HCC cells treated with α-mangostin was reduced. The expression of key stemness transcription factors, such as Bmi-1, c-Myc and Nanog, were also suppressed following α-mangostin treatment. In conclusion, α-mangostin has been shown to have anti-proliferative effects in HCC cells and malignantly transformed hepatic cells. This work discovered the potential effect of α-mangostin in HCC prevention and treatment.