Flaxseed lignan secoisolariciresinol diglucoside ameliorates experimental colitis induced by dextran sulphate sodium in mice. (October 2016)

• Record Type: Journal Article
• Authors: Xu, Jiqu; Tian, Guangjing; Ma, Congcong; Gao, Hui; Chen, Chang; Yang, Wei; Deng, Qianchun; Huang, Qingde; Ma, Zhonghua; Huang, Fenghong
• Is Part Of: Journal of functional foods. Volume 26(2016)
• Page Start: 187
• Page End: 195
• Publication Date: 2016-10
• Subjects: Secoisolariciresinol diglucoside -- Ulcerative colitis -- Dextran sulphate sodium -- Inflammation -- Mucosal permeability; Functional foods -- Analysis -- Periodicals; Food -- Biotechnology -- Periodicals; Nutrition -- Periodicals; 613.2
• DOI: 10.1016/j.jff.2016.07.013
• Languages: English
• ISSNs: 1756-4646

Abstract

Highlights: Oral SDG treatment suppressed DSS-induced colon injury. Oral SDG treatment decreased DSS-induced histological changes. Oral SDG treatment inhibited DSS-induced inflammation. Oral SDG treatment decreased colonic mucosal permeability. Abstract: The effect of flaxseed lignan secoisolariciresinol diglucoside (SDG) on ulcerative colitis was examined. Experimental colitis was induced in mice by administering 5% dextran sulphate sodium (DSS). SDG in doses of 100 and 200 mg/kg/day and 5-aminosalicylic acid (positive control) were given orally for 3 days before and during DSS administration. Oral SDG treatment significantly decreased the disease activity index and increased colon length. Histological examination revealed that the oral administration of SDG suppressed DSS-induced erosion, ulceration, crypt abscesses and oedema. Furthermore, colonic myeloperoxidase activity and TNF-α expression declined remarkably following treatment with SDG. Additionally, oral SDG treatment significantly increased the expression of several mucoprotection markers, to include zona occludens-1, Tollip and trefoil factor 3, and thus restored intestinal permeability. These results suggested that oral SDG treatment can alleviate DSS-induced colitis and might be a promising supplement for the amelioration of inflammatory bowel disease.