Antioxidant and anti-inflammatory activities of pyranoanthocyanins and other polyphenols from staghorn sumac (Rhus hirta L.) in Caco-2 cell models. (January 2016)

• Record Type: Journal Article
• Authors: Peng, You; Zhang, Hua; Liu, Ronghua; Mine, Yoshinori; McCallum, Jason; Kirby, Chris; Tsao, Rong
• Is Part Of: Journal of functional foods. Volume 20(2016)
• Page Start: 139
• Page End: 147
• Publication Date: 2016-01
• Subjects: Staghorn sumac -- Rhus hirta L. -- Anti-inflammatory activity -- Antioxidant activity -- IL-8 -- NF-κB; Compound 1–6 were not found in the PubChem Compound Database -- Gallic acid 7 (PubChem CID: 370) -- Quercetin 8 (PubChem CID: 5280343) -- Ellagic acid 9 (PubChem CID: 5281855) -- Peonidin (chloride) 10 (PubChem CID: 164544); Functional foods -- Analysis -- Periodicals; Food -- Biotechnology -- Periodicals; Nutrition -- Periodicals; 613.2
• DOI: 10.1016/j.jff.2015.10.026
• Languages: English
• ISSNs: 1756-4646

Abstract

Highlights: First report on cell-based antioxidant activity of pyranoanthocyanins and other polyphenols of staghorn sumac fruits. First report on anti-inflammatory effect of pyranoanthocyanins and other polyphenols of staghorn sumac fruits. First report on potential mechanism of anti-inflammatory effect of staghorn pyranoanthocyanins Results suggest staghorn sumac or its major components may be beneficial to inflammation related diseases such as IBD. Abstract: The antioxidant and anti-inflammatory activities of the novel pyranoanthocyanins and other polyphenols from staghorn sumac ( Rhus hirta L.) were examined. The results not only confirmed the previously found antioxidant activity by chemical based assays, but more importantly strong anti-inflammatory activity for the first time in cell-based assays. These unique compounds significantly inhibited the production of pro-inflammatory cytokine IL-8 production stimulated by H2 O2 and TNF-α. It was also found that these activities of the crude extract were primarily from the individual polyphenols, particularly the unique pyranoanthocyanins and 7-methoxyanthocyanins. Pyranoanthocyanin1, in particular, showed a markedly strong anti-inflammatory activity at 1 M, followed by pyranoanthocyanin2 and a 7-methoxyanthocyanin5 . Further mechanism investigation showed that the anti-inflammatory activity was likely mediated through inhibition of NF-κB activation via phosphorylation of IκBα. Results from the present study warrant further investigation into the in vivo anti-inflammatory effect and health benefits using animal models or human subjects.