Anti-diabetic functional foods as sources of insulin secreting, insulin sensitizing and insulin mimetic agents. (January 2016)

• Record Type: Journal Article
• Authors: Kazeem, Mutiu Idowu; Davies, Theophilus Clavell
• Is Part Of: Journal of functional foods. Volume 20(2016)
• Page Start: 122
• Page End: 138
• Publication Date: 2016-01
• Subjects: GLUT-1 Glucose-transporter 1 -- GLUT-2 Glucose-transporter 2 -- GLUT-3 Glucose-transporter 3 -- GLUT-4 Glucose transporter 4 -- SUR1 Sulphonylurea receptor 1 -- HOMA-β Homeostasis model assessment of β-cell function -- HOMA-IR Homeostasis model assessment of insulin resistance -- QUICKI Quantitative insulin sensitivity check index -- HDL-C High density lipoprotein cholesterol -- AMPK 5-AMP-activated protein kinase -- PI3-K Phosphatidylinositol-3-kinase -- IRS Insulin receptor substrate -- SOD Superoxide dismutase -- GPx Glutathione peroxidase -- GSH Reduced glutathione -- CAT Catalase -- MAPK Mitogen-activated protein kinases -- PPARγ Peroxisome proliferator activator receptor-γ; Diabetes -- Antidiabetic drugs -- Insulin -- Functional foods -- Pancreatic β-cell; Eugenol (PubChem CID: 3314) -- Carvacrol (PubChem CID: 10364) -- Apigenin (PubChem CID: 5280443) -- Theobromine (PubChem CID: 5429) -- Safranal (PubChem CID: 10364) -- Oleuropein (PubChem CID: 5281544) -- Emodin (PubChem CID: 3220) -- Girinimbine (PubChem CID: 96943) -- Curcumin (PubChem CID: 969516) -- Betulin (PubChem CID: 72326); Functional foods -- Analysis -- Periodicals; Food -- Biotechnology -- Periodicals; Nutrition -- Periodicals; 613.2
• DOI: 10.1016/j.jff.2015.10.013
• Languages: English
• ISSNs: 1756-4646

Abstract

Highlights: This review presents foods with insulin modulatory potentials. Different experimental models to study insulin modulatory effects were presented. Most of the foods exhibited insulin secreting and insulin sensitizing potentials. Pure compounds have been isolated from some of the food plants. Abstract: Diabetes mellitus is one of the most widespread diseases in the world and all efforts to find its cure have so far proved unsuccessful. However, management of this disease by the usage of oral antidiabetic drugs and dietary therapy has shown some promise. Since insulin is the primary regulator of diabetes, any food that could enhance the secretion and action of insulin will be useful in the treatment of this disease. Several studies have been conducted on the insulin modulatory potential of some foods and food products, but there is no repository with information on these foods. This paper attempts to integrate available information on functional foods with insulin secreting, insulin sensitizing and insulin mimetic properties. It is hoped that the information provided will encourage future research on these foods with the aim of isolating the active components for functional food ingredients as well as nutraceuticals, and probably drug development.