A concept for classification of optimal breathing pattern for use in radiotherapy tracking, based on respiratory tumor kinematics and minimum jerk analysis. Issue 6 (1st June 2016)

• Record Type: Journal Article
• Authors: Anetai, Yusuke; Sumida, Iori; Takahashi, Yutaka; Yagi, Masashi; Mizuno, Hirokazu; Ota, Seiichi; Suzuki, Osamu; Tamari, Keisuke; Seo, Yuji; Ogawa, Kazuhiko
• Is Part Of: Medical physics. Volume 43:Issue 6(2016)Part 1
• Page Start: 3168
• Page End: 3177
• Publication Date: 2016-06-01
• Subjects: kinematics -- patient monitoring -- pneumodynamics -- radiation therapy -- tumours; Therapeutic applications, including brachytherapy -- Pneumodyamics, respiration; Radiation therapy; CyberKnife -- synchrony -- respiratory tracking -- respiratory training -- respiratory monitoring -- respiratory coaching -- gated radiotherapy; Cancer -- Kinematics -- Pneumodynamics -- Radiation treatment -- Radiation therapy -- Trajectory models -- Robotics -- Medical imaging -- Computer modeling -- Image detection systems; Medical physics -- Periodicals; Medical physics; Geneeskunde; Natuurkunde; Toepassingen; Biophysics; Periodicals; Periodicals; Electronic journals; 610.153
• DOI: 10.1118/1.4951731
• Languages: English
• ISSNs: 0094-2405

Abstract

Abstract : Purpose: During radiotherapy, maintaining the patient in a relaxed and comfortable state helps ensure respiratory regularity and reproducibility, thereby supports accurate respiratory tracking/gating treatment. Criteria to evaluate respiratory naturalness, regularity, and phase robustness are therefore needed to aid for the treatment system numerically and medical observers visually. This study introduces a new concept of respiratory tumor kinematics that describes the trajectory of tumor motion with respiration, leading to the minimum jerk theory. Using this theory, this study proposes novel respiratory criteria for respiratory naturalness, regularity, and phase robustness. Methods: According to respiratory tumor kinematics, tumor motion follows the minimum curvature/jerk trajectory in 4D spacetime. Using this theory, the following three respiratory criteria are proposed: (1) respiratory naturalness U s, the residual sum of the squared difference between the normalized average free respiratory wave (single inhalation/exhalation averaged over each 10 phases) and the normalized minimum jerk theoretical respiratory wave; (2) respiratory regularity C j 16, the cumulative jerk squared cost function sampling every 0.2 s with a peak adjustment coefficient, 16; and (3) respiratory phase robustness ( L Δ ), a second‐order partial differential in the respiratory position for regarded C j 16 as the respiratory position function. To verify these respiratory criteria, values obtained from CyberKnife tracking marker log data for 15 patients were compared with regard to the correlation error between the correlation model and the imaged tumor position, as well as with the number of remodels. The C j 16 growth curve was also compared between 15 patients and 15 healthy volunteers. Results: In the 15 patients, data with U s < 1 and C j 16 (60 s) < 10 000 satisfied average/maximum correlation errors of less than 1/3 mm. Data with higher U s values (less respiratory naturalness) and higher C j 16 (60 s) values (less respiratory regularity) demonstrated more than 3 mm average/5 mm maximum correlation errors and an increased number of remodels. The data for the 15 patients and 15 volunteers demonstrated that the C j 16 growth curve over 120 s from the start of sampling indicated patient‐specific respiratory trends and that the distribution of L Δ clearly showed the respiratory phase shift. In 22 of 30 subjects, the degree of change in the C j growth curve trends from 60 to 120 s was 22% ± 13% (average ± SD). In contrast, the residual data observed when C j 16 > 1000 showed minimum and mean changes of 91% and 180%, respectively. Conclusions: The authors developed and verified novel respiratory criteria for respiratory naturalness, regularity, and phase robustness obtained using respiratory tumor kinematics and minimum jerk analysis. These criteria should be useful in monitoring respiratory trends on a real‐time basis during treatment, as well as in selecting optimal breathing for tracking/gating radiation treatment and defining numerical goals for respiratory training/gating.