Characterization of p75 neurotrophin receptor expression in human dental pulp stem cells. Issue 53 (October 2016)

• Record Type: Journal Article
• Authors: Pan, Wenru; Kremer, Karlea L.; Kaidonis, Xenia; Ludlow, Victoria E.; Rogers, Mary-Louise; Xie, Jianling; Proud, Christopher G.; Koblar, Simon A.
• Is Part Of: International journal of developmental neuroscience. Issue 53(2016:Oct.)
• Page Start: 90
• Page End: 98
• Publication Date: 2016-10
• Subjects: p75 Neurotrophin receptor -- Dental pulp stem cells -- Neural crest stem cells -- SOX2 -- SOX9; Developmental neurobiology -- Periodicals; Neurology -- Periodicals; Neurologie du développement -- Périodiques; Developmental neurobiology; Periodicals; 612.8
• DOI: 10.1016/j.ijdevneu.2016.07.007
• Languages: English
• ISSNs: 0736-5748

Abstract

Highlights: Human DPSC are groups of stem cells capable of differentiating into neural cells. A small percent of p75NTR + human DPSC are of great neurogenic potential. p75NTR + DPSC also possess high expression levels of neuro-markers. p75NTR is a useful marker to isolate stem cells with high neurogenecity. Abstract: Human adult dental pulp stem cells (DPSC) are a heterogeneous stem cell population, which are able to differentiate down neural, chondrocyte, osteocyte and adipocyte lineages. We studied the expression pattern of p75 neurotrophin receptors (p75NTR), a marker of neural stem cells, within human DPSC populations from eight donors. p75NTR are expressed at low levels (<10%) in DPSC. Importantly, p75 + DPSC represent higher expression levels of SOX1 (neural precursor cell marker), SOX2 (cell pluripotency marker) and nestin (neural stem cell marker) in comparison to p75 − DPSC. Our results suggest that p75 + hDPSC may denote a subpopulation with greater neurogenic potential.