High throughput screening for discovery of materials that control stem cell fate. Issue 4 (August 2016)

• Record Type: Journal Article
• Authors: Patel, Asha K.; Tibbitt, Mark W.; Celiz, Adam D.; Davies, Martyn C.; Langer, Robert; Denning, Chris; Alexander, Morgan R.; Anderson, Daniel G.
• Is Part Of: Current opinion in solid state & materials science. Volume 20:Issue 4(2016)
• Page Start: 202
• Page End: 211
• Publication Date: 2016-08
• Subjects: Stem cells -- Differentiation -- Biomaterials -- High throughput screening -- 3D; Materials science -- Periodicals; Solid state physics -- Periodicals; 620.11
• DOI: 10.1016/j.cossms.2016.02.002
• Languages: English
• ISSNs: 1359-0286

Abstract

Graphical abstract: Highlights: An overview of material properties that guide stem cell fate is provided. The role of high throughput screening for the discovery of materials. Fabrication of two and three-dimensional screening platforms for cellular interfacing. Non-exhaustive summary of stem-cell substrates identified from screens. Technological hurdles for high throughput materials and cellular characterization. Abstract: Insights into the complex stem cell niche have identified the cell–material interface to be a potent regulator of stem cell fate via material properties such as chemistry, topography and stiffness. In light of this, materials scientists have the opportunity to develop bioactive materials for stem cell culture that elicit specific cellular responses. To accelerate materials discovery, high throughput screening platforms have been designed which can rapidly evaluate combinatorial material libraries in two and three-dimensional environments. In this review, we present screening platforms for the discovery of material properties that influence stem cell behavior.