Hematopoietic stem cells under pressure. Issue 4 (July 2017)

• Record Type: Journal Article
• Authors: Ganuza, Miguel; McKinney-Freeman, Shannon
• Is Part Of: Current opinion in hematology. Volume 24:Issue 4(2017:Jul.)
• Publication Date: 2017-07
• Subjects: bone marrow reconstituting niche -- bone marrow transplantation -- hematopoietic stem cells -- oxidative stress; Hematology -- Periodicals; Blood -- Diseases -- Periodicals; 616.15
• DOI: 10.1097/MOH.0000000000000347
• Languages: English
• ISSNs: 1065-6251

Abstract

Abstract : Purpose of review: Hematopoietic stem cells (HSCs) and progenitors are tasked with maintaining hematopoietic homeostasis in the face of numerous insults and challenges, including infection, inflammation, and exsanguination. HSCs possess the remarkable ability to reconstitute the entire hematopoietic system of an organism whose own hematopoietic system has been ablated. This ability is exploited routinely in the clinic via HSC transplantation (HSCT). Here, we focus on the physiological and molecular bottlenecks overcome by HSCs during transplantation. Recent findings: During transplantation, HSCs encounter a damaged bone marrow niche, characterized molecularly by increases in oxygen concentrations and an altered cytokine milieu. New mechanisms and pathways have been recently implicated during HSCT, including transplanted HSC-dependent secretion of conditioning molecules that facilitate engraftment and pathways that protect HSCs from perturbed organelle homeostasis. Summary: Better understanding the molecular processes HSCs employ to withstand the stress of transplant will illuminate novel targets for further improving conditioning regimens and engraftment during HSCT.