Rapid Diffusion-Weighted Magnetic Resonance Imaging of the Brain Without Susceptibility Artifacts: Single-Shot STEAM With Radial Undersampling and Iterative Reconstruction. Issue 7 (July 2017)

• Record Type: Journal Article
• Authors: Merrem, Andreas; Hofer, Sabine; Voit, Dirk; Merboldt, K.-Dietmar; Klosowski, Jakob; Untenberger, Markus; Fleischhammer, Julius; Frahm, Jens
• Is Part Of: Investigative radiology. Volume 52:Issue 7(2017:Jul.)
• Publication Date: 2017-07
• Subjects: diffusion-weighted MRI -- radial sampling -- iterative reconstruction -- Gauss-Newton method; Diagnosis, Radioscopic -- Periodicals; Radiology, Medical -- Periodicals; 616.0757
• DOI: 10.1097/RLI.0000000000000357
• Languages: English
• ISSNs: 0020-9996

Abstract

Abstract : Objective: The aim of this study was to develop a rapid diffusion-weighted (DW) magnetic resonance imaging (MRI) technique for whole-brain studies without susceptibility artifacts and measuring times below 3 minutes. Materials and Methods: The proposed method combines a DW spin-echo module with a single-shot stimulated echo acquisition mode MRI sequence. Previous deficiencies in image quality due to limited signal-to-noise ratio are compensated for (1) by radial undersampling to enhance the flip angle and thus the signal strength of stimulated echoes; (2) by defining the image reconstruction as a nonlinear inverse problem, which is solved by the iteratively regularized Gauss-Newton method; and (3) by denoising with use of a modified nonlocal means filter. The method was implemented on a 3 T MRI system (64-channel head coil, 80 mT · m gradients) and evaluated for 10 healthy subjects and 2 patients with an ischemic lesion and epidermoid cyst, respectively. Results: High-quality mean DW images of the entire brain were obtained by acquiring 1 non-DW image and 6 DW images with different diffusion directions at b = 1000 s · mm. The achievable resolution for a total measuring time of 84 seconds was 1.5 mm in plane with a section thickness of 4 mm (55 sections). A measuring time of 168 seconds allowed for an in-plane resolution of 1.25 mm and a section thickness of 3 mm (54 sections). Apparent diffusion coefficient values were in agreement with literature data. Conclusions: The proposed method for DW MRI offers immunity against susceptibility problems, high spatial resolution, adequate signal-to-noise ratio and clinically feasible scan times of less than 3 minutes for whole-brain studies. More extended clinical trials require accelerated computation and online reconstruction.