Time patterns in multiple acute cerebral infarcts. Issue 9 (December 2017)

• Record Type: Journal Article
• Authors: Novotny, Vojtech; Khanevski, Andrej N; Thomassen, Lars; Waje-Andreassen, Ulrike; Naess, Halvor
• Is Part Of: International journal of stroke. Volume 12:Issue 9(2017)
• Page Start: 969
• Page End: 975
• Publication Date: 2017-12
• Subjects: Multiple infarcts -- ischemic stroke -- magnetic resonance imaging -- diffusion-weighted magnetic resonance imaging -- carotid stenosis -- cardioembolism -- time patterns; 616.8005
• DOI: 10.1177/1747493016677979
• Languages: English
• ISSNs: 1747-4930

Abstract

Background: Multiple acute cerebral infarcts in different arterial territories may be caused by several emboli concurrently or successively. Aim and/or hypothesis: We hypothesized that the time from stroke onset to magnetic resonance imaging may shed light on underlying mechanisms of multiple acute cerebral infarcts. Methods: This is a prospective observational cohort study involving 2697 ischemic stroke patients conducted at Haukeland University Hospital between February 2006 and October 2013. Only patients with diffusion-weighted imaging lesions in more than one arterial territory (left or right anterior circulation or posterior circulation) were included. The time from stroke onset to magnetic resonance imaging was registered and correlated with the etiology of multiple acute cerebral infarcts in each patient. Results: We reviewed 2697 consecutive patients and 2220 (82%) underwent magnetic resonance imaging. Among these 2125 (96%) had diffusion-weighted imaging lesions. We found 187 multiple acute cerebral infarct patients who were then included in the study. There was positive correlation (0.20; p < .001) between time to magnetic resonance imaging and frequency of multiple acute cerebral infarcts caused by internal carotid stenosis. There was no correlation (−.02) between time to magnetic resonance imaging and frequency of multiple acute cerebral infarcts caused by cardiogenic embolism. Conclusions: Multiple acute cerebral infarcts associated with cardiogenic embolism seem to happen concurrently as a shower of emboli whereas multiple acute cerebral infarcts associated with internal carotid artery stenosis seem to occur successively separated by hours or days.