Chronic Liver Disease-Associated Hospitalizations among Adults with Diabetes, National Inpatient Sample, 2001–2012. (November 2015)

• Record Type: Journal Article
• Authors: Byrd, Kathy K.; Mehal, Jason M.; Schillie, Sarah F.; Holman, Robert C.; Haberling, Dana; Murphy, Trudy
• Is Part Of: Public health reports. Volume 130:Number 6(2015)
• Page Start: 693
• Page End: 703
• Publication Date: 2015-11
• Subjects: Public health -- United States -- Periodicals; 614.0973
• DOI: 10.1177/003335491513000619
• Languages: English
• ISSNs: 0033-3549

Abstract

Objective: Many people with diabetes have a variety of diabetes-related complications. Among the variety of conditions associated with diabetes, however, liver diseases are less well recognized. As such, we aimed to describe chronic liver disease (CLD)-associated hospitalization rates among U.S. adults with diabetes from 2001–2012. Methods: We used a nationally representative database of hospitalizations, the National Inpatient Sample, to determine CLD-associated hospitalization rates among U.S. adults aged ≥18 years with and without diabetes, from 2001–2012. Hospitalizations listing an International Classification of Diseases, Ninth Revision, Clinical Modification (ICD-9-CM) code for CLD on the discharge record were selected for analysis and were further classified by diabetes status based on concurrent presence of a diabetes ICD-9-CM code. We calculated average annual age-adjusted hospitalization rates and 95% confidence intervals (CIs), and conducted a test for trend. Results: For 2001–2012, the total age-adjusted CLD-associated hospitalization rate among adults with diabetes (1, 680.9 per 100, 000 population; 95% CI 1, 577.2, 1, 784.6) was approximately four times the rate of adults without diabetes (424.2 per 100, 000 population; 95% CI 413.4, 435.1). Total age-adjusted hospitalization rates of adults with and without diabetes increased 59% and 48%, respectively, from 2001–2002 to 2011–2012 ( p <0.001). Hepatitis C- and chronic hepatitis and cirrhosis-associated hospitalizations comprised the largest proportion of total CLD-associated hospitalizations among adults with and without diabetes. Conclusion: Providers should be aware of the potential existence of CLD among adults with diabetes and counsel patients on preventive methods to avoid progressive liver damage.