State-dependent increase in the levels of neurotrophin-3 and neurotrophin-4/5 in patients with bipolar disorder: A meta-analysis. (August 2016)

• Record Type: Journal Article
• Authors: Tseng, Ping-Tao; Chen, Yen-Wen; Tu, Kun-Yu; Wang, Hung-Yu; Chung, Weilun; Wu, Ching-Kuan; Hsu, Shih-Pin; Kuo, Hung-Chang; Lin, Pao-Yen
• Is Part Of: Journal of psychiatric research. Volume 79(2016:Aug.)
• Page Start: 86
• Page End: 92
• Publication Date: 2016-08
• Subjects: Bipolar disorder -- Mood status -- Neurotrophin -- NT-3 -- NT-4/5 -- Psychiatry; BD bipolar disorder -- NT neurotrophin -- BDNF brain-derived neurotrophic factor -- NGF nerve growth factor -- NT-3 neurotrophin-3 -- NT-4/5 neurotrophin-4/5 -- trkB tyrosine kinase NT receptor B -- trkC tyrosine kinase NT receptor C -- ES effect size -- SD standard deviation -- MOOSE Meta-analysis Of Observational Studies in Epidemiology -- BMI body mass index -- HC healthy control -- CI confidence interval; Psychiatry -- Periodicals; Mental Disorders -- Periodicals; Maladies mentales -- Périodiques; Psychiatry; Electronic journals; Periodicals; 616.89005
• DOI: 10.1016/j.jpsychires.2016.05.009
• Languages: English
• ISSNs: 0022-3956

Abstract

Abstract: Bipolar disorder (BD) is one of the most serious psychiatric disorders in the world, but its pathophysiology is still unclear. Regulation of neurotrophic factors have been thought to play a role in this process. There have been inconsistent findings regarding the differences in blood neurotrophin-3 (NT-3) and neurotrophin-4/5 (NT-4/5) between patients with BD and healthy controls (HCs). The aim of the current meta-analysis is to examine the changes in the levels of NT-3 and NT-4/5 in BD patients at different affective states. Eight articles (including 465 BD patients and 353 HCs) were included in the analysis, and their results were pooled by using a random effects model. We found the levels of both NT-3 (p = 0.0046) and NT-4/5 (p = 0.0003) were significantly increased in BD patients, compared to HCs. Through subgroup analysis, this increase persisted only in patients in depressed state (p = 0.0038 for NT-3 and p = 0.0001 for NT-4/5), but not in manic or euthymic state. In addition, we found the differences in NT-3 and NT-4/5 were significantly associated with the duration of illness, but not by the mean age or female proportion. Our results suggest a state-dependent increase in NT-3 and NT-4/5 levels in patients with BD. Further studies are needed to examine dynamic changes of these neurotrophins in BD patients along the disease course. Highlights: Meta-analysis was performed to examine blood NT-3 and NT-4/5 levels in bipolar disorder. NT-3 and NT-4/5 levels are increased in patients with bipolar disorder. These levels are increased only in patients in depressed state, but not in manic or euthymic state. Illness duration of patients was associated with the change of NT-3 and NT-4/5.