Prevalence and correlates of left ventricular diastolic dysfunction and heart failure with preserved ejection fraction in elderly community residents. (15th January 2017)

• Record Type: Journal Article
• Authors: Cui, Xiaotong; Zhou, Jingmin; Jin, Xuejuan; Zhou, Jun; Fu, Michael; Hu, Kai; Sun, Aijun; Ge, Junbo
• Is Part Of: International journal of cardiology. Volume 227(2017)
• Page Start: 820
• Page End: 825
• Publication Date: 2017-01-15
• Subjects: Diastolic dysfunction -- Heart failure -- Preserved ejection fraction -- Epidemiology -- Elderly; Cardiology -- Periodicals; Electronic journals; 616.12
• DOI: 10.1016/j.ijcard.2016.10.041
• Languages: English
• ISSNs: 0167-5273

Abstract

Abstract: Background: Left ventricular diastolic dysfunction (LVDD) is closely related to heart failure with preserved ejection fraction (HFpEF), while the prevalence and correlates of either LVDD or HFpEF in elderly population remain largely unknown. Methods: The study was performed in 1274 community residents (769 women, aged ≥ 65 years) who participated in the Shanghai Heart Health Study. Demographic, laboratory and echocardiographic data were obtained to analyze correlates of LVDD and HFpEF using univariate and multivariate Logistic analysis. Results: LVDD was detected in 31.9% (406/1274) residents and it was significantly higher in women than in men (34.2% vs. 28.3%, P = 0.027). HFpEF prevalence was 2.8% (35/1274), and increased with aging in the whole cohort. For residents with left ventricular ejection fraction ≥ 50% and normal-sized ventricular cavity, female sex (odds ratio [OR] 1.69, 95% confidence interval [CI] 1.24–2.29), heart rate (OR 0.76, 95% CI 0.68–0.86), atrial fibrillation (OR 7.37, 95% CI 3.13–17.36), hypertension (OR 1.32, 95% CI 1.00–1.75), N-terminal pro-B type natriuretic peptide (OR 2.33, 95% CI 1.50–3.61) and high-sensitivity troponin T (hs-TnT) (OR 1.90, 95% CI 1.12–3.23) were independent correlates of asymptomatic LVDD. While age (OR 1.44, 95% CI 1.01–2.06), heart rate (OR 0.66, 95% CI 0.47–0.93) and hs-TnT (OR 4.37, 95% CI 1.46–13.12) were independently related to HFpEF. Conclusions: LVDD is common in this community elderly population, and HFpEF is also not rare. Different factors played roles in different stages of HFpEF. Future studies are warranted to explore the predictors of LVDD and HFpEF in the community elderly.