Low holo-transcobalamin levels are prevalent in vegetarians and is associated with coronary artery disease in Indian population. (3rd July 2016)

• Record Type: Journal Article
• Authors: Basak, Trayambak; Garg, Gaurav; Bhardwaj, Nitin; Tanwar, Vinay Singh; Seth, Sandeep; Karthikeyan, Ganesan; Sengupta, Shantanu
• Is Part Of: Biomarkers. Volume 21:Number 5(2016)
• Page Start: 436
• Page End: 440
• Publication Date: 2016-07-03
• Subjects: Coronary artery disease -- holo-transcobalamin -- vitamin B12; Biochemical markers -- Periodicals; 610.28
• DOI: 10.3109/1354750X.2016.1153718
• Languages: English
• ISSNs: 1354-750X

Abstract

Abstract: Coronary artery disease (CAD) has been increasing alarmingly in India. We had earlier shown that vitamin B12 deficiency is associated with CAD in Indian population. However, only about a quarter of the total vitamin B12 is internalised in the cells by the proteins transcobalamin II. Vitamin B12 -bound transcobalamin II (holotranscobalamin, holoTC) is thus referred to as biologically active B12 . In this study, we ascertained the levels of holoTC in 501 CAD cases and 1253 healthy controls and for the first time show that holoTC levels are significantly lower ( p = 2.57E-4) in CAD (26.81 pmol/l) cases as compared to controls (29.97 pmol/l).