Impact of age- and gender-specific cut-off values for the fecal immunochemical test for hemoglobin in colorectal cancer screening. Issue 5 (May 2016)

• Record Type: Journal Article
• Authors: Lanas, Angel; Gonzalez-Rubio, Francisca; Moya-Calvo, Alberto; Polo-Tomas, Mónica; Pilar Roncales, Maria; Sebastian-Martínez, Pilar; Valencia-Doblas, María Ángeles; Valero-Capilla, Nieves; Bujanda, Luis; Alkiza, María E.; Altzibar, Jone; Amiano, Pilar; Arenas, Juan; Artiñano, Edurne; Cosme, Angel; Egitegi, Isabel; Elorriaga, Kepa; Elósegui, Jose L.; Enriquez-Navascués, José M.; Erce, Cristina; Gil, Inés; Gutiérrez-Stampa, María A.; Herreros, Marta; Hijona, Elizabeth; Jaúregui, Mariluz; Laredo, Eva; Martínez, Roberto; Mitxelena, Maria J.; Montalvo, Isabel; Placer, Carlos; Portillo, Isabel; Quintero, Enrique; Alarcón, Onofre; Alonso-Abreu, Inmaculada; Carrillo-Palau, Marta; de la Vega-Prieto, Mariola; Díez-Fuentes, María Luisa; Gimeno-García, Antonio; González-Méndez, Yanira; Hernández-Guerra, Manuel; Linertová, Renata; Nicolás-Perez, David; Reyes-Melián, Juana María; Andreu, Montserrat; Álvarez, Cristina; Augé, Josep M.; Balaguer, Francesc; Barau, Mercè; Bessa, Xavier; Bory, Felipe; Burón, Andrea; Castells, Antoni; Castells, Xavier; Comas, Mercè; Cuatrecasas, Míriam; Estrada, Maria; Ferrer, Olga; Garrell, Imma; Grau, Jaume; Guayta, Rafael; Hernández, Cristina; López-Cerón, María; Macià, Francesc; Moreira, Leticia; Ocaña, Teresa; Pellisé, Maria; Piracés, Mercè; Polbach, Sandra; Puigvehí, Marc; Rodríguez, Cristina; Sala, Maria; Seoane, Agustín; Serradesanferm, Anna; Sivilla, Judith; Cubiella, Joaquín; Belén Aguado, Mª; Aldecoa, Susana; Almazán, Raquel; Alonso, Ana; Castro, Inés; Cid, Estela; Cid, Lucía; Clofent, Joan; de Castro, Mª Luisa; Estévez, Pamela; Fernández, Ana Belén; Dolores González, Mª; González, Simoneta; Carmen González-Mao, Mª; Hernández, Vicent; Iglesias, Begoña; Iglesias, Felipe; Iglesias, Pilar; López-Martínez, Ángeles; Macenlle, Ramiro; Martínez, Alfonso; Martínez, David; Menéndez, Carlos; Méndez, Carmen; Hermo, José Antonio; Pérez, Isabel; Portasany, Carmen; Rionda, Mar; Rivera, Concepción; Rodríguez, Benito; Rodríguez, Rosa; Rubio, Manuel; Santiago, María Isolina; Vázquez, Miriam; Vázquez, José Ángel; Vega, Pablo; Carmen Vidal, Mª; Zubizarreta, Raquel; Diego Morillas, Juan; Abreu, Luís; Javier Amador, Francisco; Arroyo, Manuel; Bandrés, Fernando; Barba, Margarita; Blanco, José Manuel; Cacho, Guillermo; Cantero, José; Carrasco, Juan; Carrascosa, Beatriz; Castellano, Gregorio; Colina, Francisco; Chaparro, María; Díaz-Rubio, Manuel; Díaz-Tasende, José; Esteban, José Miguel; Fernández, Conrado; Fernández-Díez, Servando; Fernández-Gil, Marta; Ferrándiz, Juan; Franco, Alejandro; García-Álvarez, Gabriela; Garrido, Aurelio; Garrido, Sofía; Gisbert, Javier P.; Gómez-Haba, Mariano; Gómez-Molíns, Inés; González-Navarro, Andrés; González, María José; Herranz, Belén; Herránz, Pilar; Herreros, Alberto; Iglesias, Rosario; Izquierdo, Sonia; López, Carlos; López-Rubio, María Aranzazu; Marín, Alicia; Marín, José Carlos; Martín, María Carmen; Martínez, José Luis; Martínez, Raquel; Moliner, Carmen; Moreno, José Manuel; Moreno, Ricardo; Nogueiras, Amelia; Pérez, María Teresa; Píriz, Rafael; Plaza, Carmen; Polentinos, Elena; Povés, Carmen; Ruíz, Pedro; Salces, Inmaculada; Sánchez-Ceballos, Francisco; Santander, Cecilio; Sastre, Rocío; Valentín, Vicente; Carballo, Fernando; Alajarín, Miriam; Alberca, Fernando; Bermejo, Juan; Carrillo, Joaquín; Cruzado, José; López, Purificación; Martínez, Mariano; Navarro, María Dolores; Ono, Akiko; Parra, Soledad; Pérez-Riquelme, Francisco; Salas, Dolores; Andrés, Mercedes; Calvo, Consuelo; Jimenez, Montserrat; Málaga, Araceli; Pérez, Elena; Peris, Antonio; Ponce, Marta; Jover, Rodrigo; Sala, Teresa; Teruel, Gloria; Alvarez-Urturi, Cristina; Andreu, Montserrat; Hernandez, Cristina; Perez-Riquelme, Francisco; Carballo, Fernando; Ono, Akiko; Cruzado, Jose; Cubiella, Joaquín; Hernandez, Vicent; Mao, Carmen Gonzalez; Perez, Elena; Salas, Dolores; Andrés, Mercedes; Bujanda, Luis; Portillo, Isabel; Sarasqueta, Cristina; Quintero, Enrique; Morillas, Juan Diego; Lanas, Angel; Sostres, Carlos; Augé, Josep Maria; Castells, Antoni; Bessa, Xavier;
• Is Part Of: Digestive and liver disease. Volume 48:Issue 5(2016)
• Page Start: 542
• Page End: 551
• Publication Date: 2016-05
• Subjects: Colorectal cancer screening -- Cut-off values; Digestive organs -- Diseases -- Periodicals; Liver -- Diseases -- Periodicals; 616.33005
• DOI: 10.1016/j.dld.2016.02.001
• Languages: English
• ISSNs: 1590-8658

Abstract

Abstract: Background: There is no information on the impact of age and gender on the diagnostic yield of different positivity thresholds for the fecal immunochemical test for hemoglobin (FIT). Objectives: To evaluate the performance of this test at distinct positivity cut-offs in a population-based colorectal cancer (CRC) screening program. Methods: CRC detection rate (DR), and analysis of resources were evaluated retrospectively, at different cut-offs of FIT (20, 25, 30, 35 and 40 μg Hb/g) respect to a reference value (15 μg Hb/g), according to age and gender, in a screening population of 10, 611 participants of the ColonPrev study (Quintero. NEJM 2013). Results: At the reference cut-off value, 36 CRC and 252 advanced adenomas (AA) were diagnosed. Increasing the cut-off in women ≤60 years decreases colonoscopies performed by 44.5% without modifying the CRC (DR). Same CRC DR was observed in men ≤60 years and women >60 years increasing cut-off at 25–30 μg Hb/g. In men >60 years, all increases in the cut-off affected the CRC DR, especially when the cut-off was increased from 35 to 40 μg Hb/g (CRC miss rate 25%). Conclusions: To improve the performance of FIT in CRC screening programs, FIT cut-offs could be individualized by age and gender.