Effects of polychlorinated biphenyls on metamorphosis of a marine fish Japanese flounder (Paralichthys olivaceus) in relation to thyroid disruption. Issue 1 (15th June 2017)

• Record Type: Journal Article
• Authors: Dong, Yifei; Zhang, Xiaona; Tian, Hua; Li, Xiang; Wang, Wei; Ru, Shaoguo
• Is Part Of: Marine pollution bulletin. Volume 119:Issue 1(2017)
• Page Start: 325
• Page End: 331
• Publication Date: 2017-06-15
• Subjects: TDCs thyroid-disrupting chemicals -- PAHs polycyclic aromatic hydrocarbons -- PCBs polychlorinated biphenyls -- THs thyroid hormones -- TTR transthyretin -- TU thiourea -- T4 thyroxine -- TCDD tetrachlorodibenzo-p-dioxin -- PCB 126 3, 3′, 4, 4′, 5-pentachlorobiphenyl -- T3 triiodothyronine -- MS222 tricaine methane sulfonate -- PBS phosphate-buffered saline -- ELISA enzyme linked immunosorbent assay -- ANOVA analysis of variance -- PTU propylthiouracil -- TSH thyroid-stimulating hormone; Flatfish metamorphosis -- Morphological abnormalities -- Delayed effects -- Thyroid hormones -- Polychlorinated biphenyls; Marine pollution -- Periodicals; Marine Biology -- Periodicals; Water Pollution -- Periodicals; Mer -- Pollution -- Périodiques; Publications périodiques; Pollution des mers; Lutte antipollution; Electronic journals; 363.7394
• DOI: 10.1016/j.marpolbul.2017.04.033
• Languages: English
• ISSNs: 0025-326X

Abstract

Abstract: This study examined the influence of environmental concentrations of Aroclor 1254 (10, 100, and 1000 ng/L) on metamorphosis of Paralichthys olivaceus, and analyzed the mechanisms in relation to thyroid disruption. Results showed that 100 and 1000 ng/L Aroclor 1254 delayed metamorphosis and that 1000 ng/L Aroclor 1254 caused abnormal morphology. Thyroxine and triiodothyronine levels in the control group were significantly elevated at metamorphic climax, but treatment with 100 and 1000 ng/L delayed the increase in thyroid hormones (THs) and retarded metamorphic processes. In larvae exposed to 1000 ng/L Aroclor 1254, TH levels at metamorphic climax were significantly lower than those of the control group at the same metamorphic stage. We suggest that the effects of Aroclor 1254 on larval metamorphosis can be explained by disruption of thyroid homeostasis. These findings provide a new perspective and biological model for thyroid-disrupting chemicals (TDCs) screening and investigating interference of thyroid function by TDCs. Highlights: Aroclor 1254 retarded metamorphic processes of Paralichthys olivaceus . Aroclor 1254 delayed the increase in THs at metamorphic climax of P. olivaceus . Inhibition of Aroclor 1254 on metamorphosis was related to lower T4 and T3 levels. P. olivaceus provides a good model for studying interference of thyroid function.