FDOPA Patterns in Adrenal Glands: A Pictorial Essay. (May 2017)

• Record Type: Journal Article
• Authors: Moreau, Aurélie; Giraudet, Anne Laure; Kryza, David; Borson-Chazot, Françoise; Bournaud-Salinas, Claire; Mognetti, Thomas; Lifante, Jean-Christophe; Combemale, Patrick; Giammarile, Francesco; Houzard, Claire
• Is Part Of: Clinical nuclear medicine. Volume 42:Number 5(2017)
• Publication Date: 2017-05
• Subjects: 18F-FDOPA -- adrenal glands -- PET/CT -- pheochromocytoma; Nuclear medicine -- Periodicals; Radioisotope scanning -- Periodicals; Nuclear Medicine -- Periodicals; 616.07575
• DOI: 10.1097/RLU.0000000000001636
• Languages: English
• ISSNs: 0363-9762

Abstract

Abstract : Abstract: 18 F-FDOPA is a well-established tool to explore pheochromocytomas. It tends to replace 123 I-MIBG scan in metastatic pheochromocytomas, multiple endocrine neoplasia type 2-related tumors, succinate dehydrogenase [ubiquinone] iron-sulfur subunit-negative tumors, and succinate dehydrogenase[ZERO WIDTH SPACE]-positive lesions. To our knowledge, no study has characterized physiological and pathological adrenal glands with 18 F-FDOPA from a quantitative point of view. We report the features of different normal and pathological adrenal glands with 18 F-FDOPA. Within our series, only pheochromocytomas present a significantly increased uptake reflecting the high specificity of this tracer. Tumors such as adenomas or myelolipomas present no 18 F-FDOPA significant accumulation. Interestingly, adrenal gland hyperplasia and solitary glands do not demonstrate compensatory uptake.