Developmental Venous Anomalies Mimicking Neoplasm on 11C-Methionine PET and DSC Perfusion MRI. (May 2017)

• Record Type: Journal Article
• Authors: Harreld, Julie H.; Doubrovin, Mikhail; Butch, Elizabeth R.; Edwards, Angela; Shulkin, Barry
• Is Part Of: Clinical nuclear medicine. Volume 42:Number 5(2017)
• Publication Date: 2017-05
• Subjects: DVA -- methionine -- PET -- MRI -- CBV -- pediatric; Nuclear medicine -- Periodicals; Radioisotope scanning -- Periodicals; Nuclear Medicine -- Periodicals; 616.07575
• DOI: 10.1097/RLU.0000000000001637
• Languages: English
• ISSNs: 0363-9762

Abstract

Abstract : Abstract: Elevated relative cerebral blood volume on perfusion MRI and increased uptake on 11 C-methionine PET can be used to diagnose and guide biopsy of brain tumors but are not specific. We report increased uptake on 11 C-methionine PET associated with 4 developmental venous anomalies (DVAs) in 3 children with brain tumors, which could potentially mimic tumor and misdirect biopsy. Because DVAs are not readily visible on CT, prevention of misdirected biopsy in patients with focally elevated 11 C-methionine uptake and relative cerebral blood volume relies on close correlation with contrast-enhanced anatomic MRI to exclude DVA or other nonneoplastic etiology.