Effect of alirocumab dose increase on LDL lowering and lipid goal attainment in patients with dyslipidemia. Issue 3 (May 2017)

• Record Type: Journal Article
• Authors: Kastelein, John J.P.; Kereiakes, Dean J.; Cannon, Christopher P.; Bays, Harold E.; Minini, Pascal; Lee, L. Veronica; Maroni, Jaman; Farnier, Michel
• Is Part Of: Coronary artery disease. Volume 28:Issue 3(2017:May)
• Publication Date: 2017-05
• Subjects: alirocumab -- coronary heart disease -- dosing -- dyslipidemia -- LDL cholesterol -- proprotein convertase subtilisin kexin type 9; Coronary heart disease -- Periodicals; Coronary Disease -- Indexes; Coronary Disease -- Periodicals; 616.123005
• DOI: 10.1097/MCA.0000000000000438
• Languages: English
• ISSNs: 0954-6928

Abstract

Abstract : Objectives: The objective of this study is to report the dose response in ODYSSEY phase 3 clinical trials of proprotein convertase subtilisin kexin type 9 inhibition with alirocumab in patients not at prespecified lipid goals who received a per-protocol dose increase from 75 every 2 weeks (Q2W) to 150 mg Q2W. Methods: Patients ( n =2181) receiving statins were enrolled in six phase 3 randomized, double-blind, double-dummy trials (24–104 weeks): alirocumab versus placebo or ezetimibe 10 mg/day. The 75 mg subcutaneous Q2W dose was increased to 150 mg at week 12 if week 8 LDL cholesterol (LDL-C) was greater than or equal to 70 mg/dl (>100 mg/dl in OPTIONS studies for patients without previous coronary heart disease, but with other risk factors). LDL-C percentage reductions from baseline (on-treatment data, n =1291) were compared at week 12 versus week 24. Results: Most patients ( n =951; 73.7%) with 75 mg Q2W dose plus background statin achieved LDL-C less than 70 or less than 100 mg/dl at week 8. In 340 (26.3%) patients, alirocumab dose was increased to 150 mg Q2W at week 12, and 60.9% of these patients achieved LDL-C goals at week 24, with an additional 14.2% reduction in LDL-C from week 12 to week 24. Adverse event rates were comparable in patients with versus without a dose increase (72.4 vs. 71.8% in placebo-controlled trials; 67.0 vs. 67.6% in ezetimibe-controlled trials). Conclusion: Most patients achieved LDL-C goals with alirocumab 75 mg Q2W plus statins. Of those (26.3%) receiving a dose increase, 60.9% achieved LDL-C goals at week 24 with an additional 14.2% reduction in LDL-C.