A modified procedure for the palladium catalyzed borylation/Suzuki-Miyaura cross-coupling of aryl and heteroaryl halides utilizing bis-boronic acid. Issue 35 (2nd September 2015)
- Record Type:
- Journal Article
- Title:
- A modified procedure for the palladium catalyzed borylation/Suzuki-Miyaura cross-coupling of aryl and heteroaryl halides utilizing bis-boronic acid. Issue 35 (2nd September 2015)
- Main Title:
- A modified procedure for the palladium catalyzed borylation/Suzuki-Miyaura cross-coupling of aryl and heteroaryl halides utilizing bis-boronic acid
- Authors:
- Molander, Gary A.
Trice, Sarah L.J.
Tschaen, Brittany - Abstract:
- Abstract: A modified Pd-catalyzed method of forming aryl- and heteroarylboron species and a two-step, one-pot borylation/Suzuki-Miyaura cross coupling using the atom economical tetrahydroxydiboron (bis-boronic acid, BBA) is reported. By using ethylene glycol as an additive, the new method results in increased yields, lower BBA loading, faster reaction times, and a broader reaction scope, including previously problematic substrates such as heterocycles. Graphical abstract:
- Is Part Of:
- Tetrahedron. Volume 71:Issue 35(2015)
- Journal:
- Tetrahedron
- Issue:
- Volume 71:Issue 35(2015)
- Issue Display:
- Volume 71, Issue 35 (2015)
- Year:
- 2015
- Volume:
- 71
- Issue:
- 35
- Issue Sort Value:
- 2015-0071-0035-0000
- Page Start:
- 5758
- Page End:
- 5764
- Publication Date:
- 2015-09-02
- Subjects:
- Bis-boronic acid -- Tetrahydroxydiboron -- Borylation -- Cross-coupling
Chemistry, Organic -- Periodicals
547.005 - Journal URLs:
- http://www.elsevier.com/journals ↗
- DOI:
- 10.1016/j.tet.2015.04.026 ↗
- Languages:
- English
- ISSNs:
- 0040-4020
- Deposit Type:
- Legaldeposit
- View Content:
- Available online (eLD content is only available in our Reading Rooms) ↗
- Physical Locations:
- British Library DSC - 8796.850000
British Library DSC - BLDSS-3PM
British Library STI - ELD Digital store - Ingest File:
- 7886.xml