Psychogenic and neural visual-cue response in PD dopamine dysregulation syndrome. Issue 11 (November 2015)

• Record Type: Journal Article
• Authors: Loane, Clare; Wu, Kit; O'Sullivan, Sean S.; Lawrence, Andrew D.; Woodhead, Zoe; Lees, Andrew J.; Piccini, Paola; Politis, Marios
• Is Part Of: Parkinsonism & related disorders. Volume 21:Issue 11(2015)
• Page Start: 1336
• Page End: 1341
• Publication Date: 2015-11
• Subjects: Parkinson's disease -- Addiction -- fMRI -- Dopamine dyregulation syndrome -- Reward -- Psychiatry; Parkinson's disease -- Periodicals; Movement disorders -- Periodicals; Movement Disorders -- Periodicals; Nerve Degeneration -- Periodicals; Nervous System Diseases -- Periodicals; Parkinson Disease -- Periodicals; Tremor -- Periodicals; Parkinson, Maladie de -- Périodiques; Parkinson's disease; 616.833
• DOI: 10.1016/j.parkreldis.2015.09.042
• Languages: English
• ISSNs: 1353-8020

Abstract

Abstract: Introduction: Dopamine dysregulation syndrome (DDS) in Parkinson's disease (PD) patients refers to the compulsive use of dopaminergic replacement therapy and has serious psycho-social consequences. Mechanisms underlying DDS are not clear although has been linked to dysfunctional brain reward networks. Methods: With fMRI, we investigate behavioral and neural response to drug-cues in six PD DDS patients and 12 PD control patients in both the ON and OFF medication state. Behavioral measures of liking, wanting and subjectively 'feeling ON medication' were also collected. Results: Behaviorally, PD DDS patients feel less ON and want their drugs more at baseline compared to PD controls. Following drug-cue exposure, PD DDS patients feel significantly more ON medication, which correlates with significant increases in reward related regions. Conclusions: The results demonstrate that exposure to drug-cues increases the subjective feeling of being 'ON' medication which corresponds to dysfunctional activation in reward related regions in PD DDS patients. These findings should be extended in future studies. Visual stimuli being sufficient to elicit behavioral response through neuroadaptations could have direct implications to the management of addictive behavior. Highlights: PD patients with DDS 'want' but do not 'like' dopaminergic mediation. Sensitivity to drug cues heightens neural response. Drugcues elicit psychogenic motor benefit in PD DDS patients.