Implantation of octacalcium phosphate collagen composites (OCP/Col) after extraction of canine deciduous teeth achieved undisturbed permanent tooth eruption. (December 2016)

• Record Type: Journal Article
• Authors: Kanda, Naofumi; Matsui, Keiko; Kawai, Tadashi; Edamatsu, Hiroshi; Tanuma, Yuji; Suzuki, Osamu; Takahashi, Tetsu; Kamakura, Shinji
• Is Part Of: Archives of oral biology. Volume 72(2016)
• Page Start: 179
• Page End: 186
• Publication Date: 2016-12
• Subjects: HA hydroxyapatite -- OCP octacalcium phosphate -- OCP/Col composite of synthetic octacalcium phosphate and collagen -- β-TCP β-tricalcium phosphate; Bone regeneration -- Bone substitutes -- Tooth eruption -- Octacalcium phosphate -- Collagen -- Canine; Mouth -- Periodicals; Mouth -- Diseases -- Periodicals; Dentistry -- Periodicals; Electronic journals; 617.6005
• DOI: 10.1016/j.archoralbio.2016.08.027
• Languages: English
• ISSNs: 0003-9969

Abstract

Highlights: Influence of implanted OCP/Col after extraction of deciduous teeth was examined. No unerupted permanent successor teeth were observed after implantation of OCP/Col. OCP/Col did not influence the eruptive position of the permanent successor tooth. Implantation of OCP/Col preserved the alveolar heights to physiological group. The implanted OCP/Col were resorbed and replaced by newly formed bone. Abstract: Objective: Composite of synthetic octacalcium phosphate and collagen (OCP/Col) enhances bone regeneration if implanted into human, canine, or rodent bone defects. This study was designed to investigate the influence on eruption of the permanent successor tooth and alveolar height of OCP/Col implantation into extraction cavities of deciduous teeth. Design: Disks of OCP/Col prepared from synthetic granules of octacalcium phosphate (OCP) and porcine atelocollagen, and commercially available sintered porous β-tricalcium phosphate (β-TCP) was implanted into the prepared defect of eleven male beagle dogs by extraction of two deciduous premolars. Untreated group had nothing implanted into the prepared defect, and physiological group (Physiol group) was observed without any treatment. Periodical macroscopic and radiographic examinations were performed until the period equivalent to the physiological eruption of permanent successor teeth (P3 and P4). Results: Although no unerupted permanent successor teeth were observed among the OCP/Col, Untreated, and Physiol groups, two permanent successor teeth were unerupted in the β-TCP group. No significant difference of the alveolar heights or the eruptive position in P3 and P4 was observed between OCP/Col and Physiol groups. Conclusion: OCP/Col implantation in the alveolar region that included the unerupted permanent successor teeth would cause no disturbance of permanent tooth eruption and preserve the alveolar ridge.