Emergence of antigenic variants within serotype A FMDV in the Middle East with antigenically critical amino acid substitutions. Issue 27 (8th June 2016)

• Record Type: Journal Article
• Authors: Mahapatra, Mana; Statham, Bob; Li, Yanmin; Hammond, Jef; Paton, David; Parida, Satya
• Is Part Of: Vaccine. Volume 34:Issue 27(2016)
• Page Start: 3199
• Page End: 3206
• Publication Date: 2016-06-08
• Subjects: FMD virus -- Antigenic variation -- Capsid sequence -- Epitopes -- Polyclonal antibodies -- Antigenic determinants; Vaccines -- Periodicals; 615.372
• DOI: 10.1016/j.vaccine.2016.02.057
• Languages: English
• ISSNs: 0264-410X

Abstract

Highlights: The recent A-Iran-05 viruses circulating in the Middle East do not match with the existing vaccines. Full capsid sequence of 13 SIS-10 and SIS-12 viruses was generated. The r 1 -values generated using antisera raised against two existing vaccines and a new vaccine. Amino acid changes in neutralizing antigenic sites 1, 2 and 4 were observed. Abstract: A new immunologically distinct strain (A-Iran-05) of foot-and-mouth disease virus serotype A emerged in the Middle East in 2003 that replaced the previously circulating strains (A-Iran-96 and A-Iran-99) in the region. This resulted in introduction of a new vaccine of this strain (A/TUR/2006) in 2006. Though this vaccine strain has been predominantly used to control FMD in the region, recent viruses isolated in 2012 and 2013 have shown antigenic drift and a poor match with it. In this study, we report the antigenic matching results and capsid sequence data of currently circulating viruses belonging to the SIS-10 and SIS-12 sub-lineages of A-Iran-05 (isolated in 2012 and 2013), highlighting the inadequacy of the currently used serotype A vaccines. Implications of these results in the context of FMD control in the Middle East are discussed.